| Project/Area Number |
25670795
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Azuma Miyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90255654)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Tatsukuni 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80435635)
TUSHIMA Humihiko 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (90456210)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯学 / 免疫学 / 慢性炎症 / 口腔粘膜 / IL-33 / 免疫抑制分子 / VISTA / 皮膚 / 免疫制御 |
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| Outline of Final Research Achievements |
Oral mucosa induced a rapid destruction of epithelium and severe infiltration, however, this recovered quickly. Impaired generation of effector T cells and increment of regulatory T cells (Tregs) in the secondary lymphoid tissues may contribute to rapid tissue repair by suppressive mechanisms of T cell activation. Our results in a happen-induced contact hypersensitivity model indicate that a novel coinhibitory molecule VISTA functions regulatory in the induction phase of T cell activation, but not at the effector phase. Although IL-33 acts as an alarmin in both innate and adaptive immunity, Il-33 is also involved in generation, activation, and recruitment of Tregs. These opposite actions disrupt the final outcome in skin and mucosal inflammation.
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