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The evolution of genetical assessment for persistent apical periodontitis.

Research Project

Project/Area Number 25670809
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

Itoh Shousaku  大阪大学, 歯学部附属病院, 講師 (90360495)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords根尖性歯周炎 / IL-1B / SNP / 難治性根尖性歯周炎 / SNPs / 難治根尖性歯周炎
Outline of Final Research Achievements

The aim of this study is to investigate the relationship between persistent apical periodontitis and SNP of inflammatory cytokine, IL-1B. We investigated the relationship of the SNP in the intron of IL-1B, SNPID:rs1143643. Though the previous reports, from Caucasoid, showed the relationship between the SNP in the intron of IL-1B and persistent apical periodontitis, our study, from Mongoloid, showed no relationship. We concluded that the efficacy of SNP were different among the racial difference, such as Mongoloid and Caucasoid.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Density Gradient Centrifugation for the Isolation of Cells of Multiple Lineages.2015

    • Author(s)
      Yamamoto Y, Itoh S, Yamauchi Y, Matsushita K, Ikeda S, Naruse H, Hayashi M
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 116 Issue: 12 Pages: 2709-2714

    • DOI

      10.1002/jcb.25270

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] LIF/STAT3/SOCS3 Signaling Pathway in Murine Bone Marrow Stromal Cells Suppresses Osteoblast Differentiation.2014

    • Author(s)
      Matsushita K, Itoh S, Ikeda S, Yamamoto Y, Yamauchi Y, Hayashi M
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 108 Issue: 7 Pages: 1262-1268

    • DOI

      10.1002/jcb.24777

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] First mouse model for combined osteogenesis imperfecta and ehlers-danlos syndrome.2014

    • Author(s)
      Chen F, Guo R, Itoh S, Moreno L, Rosenthal E, Zappitelli T, Zirngibl RA, Flenniken A, Cole W, Grynpas M, Osborne LR, Voge W, Adamson L, Rossant J, Aubin JE
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 29 Issue: 6 Pages: 1412-1423

    • DOI

      10.1002/jbmr.2177

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation.2014

    • Author(s)
      Fujikawa J, Tanaka M, Itoh S, Fukushi T, Kurisu K, Takeuchi Y, Morisaki I, Wakisaka S, Abe M
    • Journal Title

      Cell Tissue Research

      Volume: 358 Issue: 1 Pages: 177-187

    • DOI

      10.1007/s00441-014-1931-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 修復処置におけるう蝕象牙質除去の客観性についての臨床的評価2013

    • Author(s)
      伊藤祥作
    • Journal Title

      日歯保存誌

      Volume: 56(5) Pages: 441-453

    • NAID

      110009830602

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス骨髄由来新規間葉系幹細胞集団における神経分化能の解析2015

    • Author(s)
      伊藤祥作、山内裕香子、山本由美子、成瀬陽菜、伊藤勇紀、林美加子
    • Organizer
      第143回日本歯科保存学会秋季学術大会
    • Place of Presentation
      東京都・文京区・文京シビックホール
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症誘導における新規核内制御因子NAF1の解析2014

    • Author(s)
      板東秀典、熱海 徹、小椋英樹、村上正晃、伊藤祥作、林 美加子
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 骨芽細胞の細胞表面マーカー解析法の開発2014

    • Author(s)
      山本由美子、伊藤祥作、松下健太、池田峻、山内裕香子、林 美加子
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      大津
    • Year and Date
      2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel method for surface marker analysis of mature osteoblasts2014

    • Author(s)
      Shousaku Itoh
    • Organizer
      2014 Herbert Fleisch Workshop
    • Place of Presentation
      ベルギー
    • Related Report
      2013 Research-status Report
  • [Presentation] 炎症惹起におけるNAF1の分子機構解析2013

    • Author(s)
      板東秀典、伊藤祥作
    • Organizer
      第138回日本歯科保存学会春季学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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