| Project/Area Number |
25670817
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
YATANI HIROFUMI 大阪大学, 歯学研究科(研究院), 教授 (80174530)
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| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 東北大学, 大学院歯学研究科, 教授 (30379078)
佐伯 万騎男 新潟大学, 医歯学系, 教授 (30273692)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 破骨細胞 / 骨吸収抑制 / コリン作動系 |
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| Outline of Final Research Achievements |
Severe resorption of alveolar bone after tooth loss/extraction, makes it difficult to restore the missing teeth with dental implants or prosthodontic approaches. Bone resorption is the unique function of the osteoclast, and anti-resorption therapy to date has targeted this cell. Objectives of this study is to investigate the involvement of MLA in osteoclastogenesis. MLA significantly inhibited the formation of TRAP-positive multinucleated osteoclasts in a concentration-dependent manner. These results suggest, that MLA suppresses osteoclastogenesis and that application of MLA enables to promote new bone formation. These findings represent MLA may be useful for therapeutic strategies against alveolar bone resorption in prosthetic treatments.
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