| Project/Area Number |
25670829
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Osamu 東北大学, 歯学研究科(研究院), 教授 (60374948)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIIE Junichi 麻布大学, 獣医学部, 准教授 (10400269)
ANADA Takahisa 東北大学, 大学院歯学研究科, 准教授 (30398466)
KAWAI Tadashi 東北大学, 大学病院, 助教 (50547263)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生体材料 / 表面 / 水和 / セラミックス / リン酸カルシウム / 骨伝導 / 水和層 / 吸着 |
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| Outline of Final Research Achievements |
The present study was designed to investigate about whether surface hydrated structure of calcium phosphate materials is associated with their biocompatibility and osteoconductivity. Fluoride-containing hydroxyapatite was synthesized according to our previous report (Shiwaku et al. Acta Biomater 2012) and subjected to analyze non-apatitic and apatitic HPO4 and OH ions in the structure by FTIR cure fitting. The hydrolysis progress was shown to relate to the change of HPO4 content. Because it has been suggested that the conversion process from HA precursor to HA may be involved in increasing the osteoconductivity of the calcium phosphate materials, the degree of crystallization from the precursor phases to HA was investigated by immersing the HA precursors in simulated body fluid. It was apparent that the hydrolysis of OCP is enhanced in the co-presence of ACP and the process can be detected by monitoring the surface OH ions in the hydrated structure through FTIR cure fitting analysis.
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