| Project/Area Number |
25670839
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUTA Michito 福岡歯科大学, 生体工学分野, 講師 (40507802)
ARAHIRA Takaaki 福岡歯科大学, 生体工学分野, 助教 (30706958)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アパタイト / 骨補填材 |
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| Outline of Final Research Achievements |
The aim of this study was to establish fabricate methods for fast-setting spherical α-TCP particle aggregates with continuous pore structure and for sealing membrane made of crosslinked γ-PGA. Setting time for the spherical particles mixed with 0.25M disodium hydrogen phosphate solution containing 0-5% γ-PGA was increased with γ-PGA concentration. It was possible to prepare γ-PGA gel sealing membrane by cross-linking with lysine. Bone defect in femur of Japanese rabbit (17w, male) was filled with α-TCP microsphere aggregates and sealed with γ-PGA hydrogel seat. One month after the operation, the microspheres began to dissolve or absorbed and two month later they completely disappeared from the bone defect. However, calcification of regenerated cortical bone was promoted. It was concluded that further study was needed to develop the bone regeneration system.
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