| Project/Area Number |
25670840
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
戸塚 靖則 北海道大学, -, 名誉教授 (00109456)
北村 哲也 北海道大学, 歯学研究科(研究院), 助教 (00451451)
進藤 正信 北海道大学, 歯学研究科(研究院), 教授 (20162802)
安田 元昭 北海道大学, 歯学研究科(研究院), 准教授 (90239765)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アデノウイルス / GFP / センサー / 腫瘍 / 溶解 |
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| Outline of Final Research Achievements |
In this study, we developed a cancer sensor by applying oncolytic adenovirus which we exploited in the previous study. We didn’t succeed to produce a GFP including adenovirus, but noticed that the co-infection of two kinds of viruses, a GFP-expressing adenovirus and an our oncolytic adenovirus, is available for a cancer sensor. In cancer cell such as HeLa and H1299, GFP was activated by co-infection with our oncolytic adenovirus, whereas it was not activated in normal BJ cells. The data indicates that co-infection of these virus is suitable for a cancer sensor.
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