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Investigation of novel antiangiogenic therapy against oral cancer targeting synaptic adhesion molecules

Research Project

Project/Area Number 25670843
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

YANAGAWA Toru  筑波大学, 医学医療系, 准教授 (10312852)

Co-Investigator(Kenkyū-buntansha) KATSUHIKO Tabuchi  信州大学, 医学部, 教授 (20546767)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシナプス接着因子 / ニューロリギン / ニューレキシン
Outline of Final Research Achievements

Synaptic adhesion molecules are cell adhesion factors that modulate synaptic formation and function through interaction of molecules by the extracelluar domain. Recent study showed some synaptic adhesion molecules regulated during vessel remodeling and form endogenous complexes. Then, we focused angiogenesis of oral cancer, and we investigated if we can use synaptic adhesion molecules as novel molecular target for antiangiogenic therapy for oral cancer. We investigated the relation between the expression of synaptic adhesion molecules and clinical factors of oral cancer. On the other hand we investigated molecular basis of synaptic adhesion molecules by using biochemical and developmental biological methods, such as in utero electroporation. We found there was significant difference in prognosis, however, supportive result which suggest abnormal angiogenic change was not obtained by in vivo experiment.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Enhanced synapse remodeling as a common phenotype in mouse models of autism.2014

    • Author(s)
      Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and Okabe, S.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 4742-4742

    • DOI

      10.1038/ncomms5742

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins2014

    • Author(s)
      Um, J, et al.
    • Journal Title

      Cell Rep

      Volume: 6 Pages: 1096-1109

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity2014

    • Author(s)
      Azuma, M, et al.
    • Journal Title

      Head Face Med

      Volume: 10 Issue: 1 Pages: 45-45

    • DOI

      10.1186/1746-160x-10-45

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking.2013

    • Author(s)
      Aoto J, Martinelli DC, Malenka RC, Tabuchi K, Sudhof TC.
    • Journal Title

      Cell

      Volume: 154(1) Issue: 1 Pages: 75-88

    • DOI

      10.1016/j.cell.2013.05.060

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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