Establishment of new psychosedation that can effectively acquire amnesia

• Project/Area Number: 25670858
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TOMIOKA Shigemasa 徳島大学, 大学院医歯薬学研究部, 准教授 (70188770)
• Co-Investigator(Kenkyū-buntansha): MIYAWAKI Takuya 岡山大学, 医歯薬学総合研究科, 教授 (00219825)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 健忘作用 / シナプス外GABA受容体

Outline of Final Research Achievements

We examined the effects of midazolam and propofol on the function of extrasynaptic GABAA receptor, α5β3γ2 GABAA receptor, that appear to play an important physiological role in the memory process, using Xenopus oocytes expression system. We suggest that midazolam or propofol increased the currents evoked by GABA in oocytes expressing α5β3γ2 GABAA receptor but the currents induced by midazolam was high as compared with that induced by propofol, and that the currents induced by the combination of midazolam and propofol were higher than the sum of each current induced by administration of midazolam alone and propofol alone.