|Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|Outline of Final Research Achievements
We examined the effects of midazolam and propofol on the function of extrasynaptic GABAA receptor, α5β3γ2 GABAA receptor, that appear to play an important physiological role in the memory process, using Xenopus oocytes expression system. We suggest that midazolam or propofol increased the currents evoked by GABA in oocytes expressing α5β3γ2 GABAA receptor but the currents induced by midazolam was high as compared with that induced by propofol, and that the currents induced by the combination of midazolam and propofol were higher than the sum of each current induced by administration of midazolam alone and propofol alone.