Genome-wide association study identifies novel temporomandibular joint osteoarthritis susceptibility loci
| Project/Area Number |
25670881
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
KIMURA Ryosuke 琉球大学, 亜熱帯島嶼科学超域研究推進機構, 准教授 (00453712)
INOUE Ituro 国立遺伝学研究所, 総合遺伝研究系, 教授 (00192500)
TOMOYASU Yoko 昭和大学, 歯学部 (50551206)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ゲノムワイド関連解析 / 変形性関節症 / 遺伝（子） / ゲノム / 咬合異常 / 遺伝(子) |
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| Outline of Final Research Achievements |
We have conducted the first GWAS to identify susceptibility genes underlying degenerative bony changes of the TMJ that were diagnosed by examination of a panoramic radiograph and/or MRI and/or CT images. As a result, 41 SNPs located in 22 independent loci showing association signals with degenerative bony changes of the TMJ. Our data may be useful for a future meta-analysis of
GWAS data sets.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Genome-wide SNP analysis reveals population structure and demographic history of the Ryukyu Islanders in the southern part of the Japanese Archipelago2014
Author(s)
Sato T., Nakagome S., Watanabe C., Yamaguchi K., Kawaguchi A., Koganebuchi K., Haneji K., Yamaguchi T., Hanihara T., Yamamoto K., Ishida H., Mano S., Kimura R., Oota H.
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Journal Title
Molecular Biology and Evolution
Volume: 31(11)
Issue: 11
Pages: 2929-2940
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A genome-wide association study of third molar agenesis in Japanese and Korean populations2013
Author(s)
Haga S, Nakaoka H, Yamaguchi T, Yamamoto K, Kim YI, Samoto H, Ohno T, Katayama K, Ishida H, Park SB, Kimura R, Maki K, Inoue I
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Journal Title
Journal of Human Genetics
Volume: 58
Issue: 12
Pages: 799-803
DOI
Related Report
Peer Reviewed
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