| Project/Area Number |
25670895
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SAITO Toshiyuki 長崎大学, 医歯学総合研究科(歯学系), 教授 (10170515)
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| Co-Investigator(Kenkyū-buntansha) |
FURUGEN Reiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)
HAYASHIDA Hideaki 長崎大学, 病院(歯学系), 講師 (20238140)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯周病 / NASH / 3次元培養 / アディポカイン / ＮＡＳＨ |
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| Outline of Final Research Achievements |
For the development of NASH, obesity is a state of fatty liver due to 1st Hit, and it is necessary to 2nd Hit by endotoxin (LPS) and various cytokines. It is unexplained part for of this processes. In this study, we cultured liver cells and vascular endothelial cells, ICAM-1 and P-selectin of adhesion molecules of the cells and various cytokines after stimulation with periodontal disease-related bacteria-derived LPS. Currently, we are also analyzed the influence in co-culture with human monocytic cells and neutrophils and 3D culture on the artificial membrane matrix.
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