Prevalence and clinical features of restless legs syndrome among Japanese pregnant women

• Project/Area Number: 25670973
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Lifelong developmental nursing
• Research Institution: Nagasaki University
• Principal Investigator: ETO Hiromi 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (10213555)
• Co-Investigator(Kenkyū-buntansha): OKA Yasunori 愛媛大学, 医学部附属病院, 准教授 (60419025)
• Co-Investigator(Renkei-kenkyūsha): HORIUCHI Shigeko 聖路加国際大学, 看護学部, 教授 (70157056) ; NISHIHARA Kyoko (公財)労働科学研究所, 研究員 (80172683)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 乳児 / 妊婦 / フェリチン / 睡眠時周期性四肢運動 / RLS / 鉄 / 葉酸 / 乳幼児突然死症候群 / 周産期アウトカム

Outline of Final Research Achievements

Aims: To determine the prevalence of restless legs syndrome (RLS) among Japanese pregnant women, and clarify correlation between RLS and clinical outcomes. Methods: RLS screening was conducted using the Johns Hopkins Telephone Diagnostic Interview for low-risk 140 and high-risk 81 pregnant women in their third trimester. Blood test and biochemistry results, and delivery outcomes were compared between the RLS group and the control group. Results: RLS was experienced by 22 (15.7%) of the 140 women, and 14 (17.3%) of the 81 women. No significant difference was found for hemoglobin, serum ferratin, serum folate levels and delivery outcomes between the RLS group and the control group. Conclusion: The prevalence of RLS was high in Japanese pregnant women whose pregnancy courses were good with no complications.

Research Products

• [Presentation] 妊婦のレストレスレッグス症候群（RLS）における周期性下肢運動について (2015)
  • Author(s): 坂本遥，畑中愛，山口ゆかり，江藤宏美，近藤英明
  • Organizer: 第31回不眠研究会
  • Place of Presentation: 東京ステーションホテル（東京）
  • Year and Date: 2015-12-05
• [Presentation] Restless Legs Syndrome during Pregnancy and Birth Outcome (2015)
  • Author(s): Satoko Araki, Yukari Yamaguchi, Hiromi Eto
  • Organizer: 11th ICM (International Confederation of Midwives) Asia Pacific Regional Conference 2015
  • Place of Presentation: Pacifico Yokohama, Japan
  • Year and Date: 2015-07-20
  • Int'l Joint Research
• [Presentation] 妊産婦におけるレストレスレッグス症候群の有病率と臨床像 (2015)
  • Author(s): 近藤英明・江藤宏美
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木県総合文化センター（宇都宮）
  • Year and Date: 2015-07-02
• [Presentation] 妊娠期におけるレストレスレッグス症候群のスクリーニングと実態 (2014)
  • Author(s): 畑中愛，山口ゆかり，江藤宏美，近藤英明
  • Organizer: 第30回不眠研究会
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2014-12-06
• [Presentation] Presence of restless leg syndrome and iron deficiency among third trimester of pregnant women in a Japanese urban clinic (2014)
  • Author(s): Yukari Yamaguchi, Hiromi Eto, Yasunori Oka
  • Organizer: 22nd Congress of the European Sleep Research Society
  • Place of Presentation: Nordea Concert Hall, Solaris Tallinn (Estonia)
  • Year and Date: 2014-09-16 – 2014-09-20