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Elucidation of functional role and neural mechanisms of spontaneous eyeblinks

Research Project

Project/Area Number 25700014
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Cognitive science
Research InstitutionOsaka University

Principal Investigator

NAKANO Tamami  大阪大学, 生命機能研究科, 准教授 (90589201)

Co-Investigator(Renkei-kenkyūsha) KITAZAWA Shigeru  大阪大学, 生命機能研究科, 教授 (00251231)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords瞬目 / アセチルコリン / VBM / TMS / fMRI / 自発性瞬目 / 心拍 / 自律神経 / デフォルトモードネットワーク / 脳活動 / 注意 / 海馬 / 視覚 / 遺伝子変異 / ドーパミン / ニコチン受容体
Outline of Final Research Achievements

People spontaneously blink 20 times per min, much more than necessary for ocular lubrication. However, functional role of spontaneous eyeblinks remains unknown. The present study aimed to explore the functional role and the neural mechanisms of the spontaneous eyeblinks. We found that the default mode network, the hippocampus and the orbitofrontal cortex transiently increased the neural activity in associated with eyeblinks, while the dorsal and ventral attention networks decreased their neural activity. Moreover, the genetic variation of nicotinic cholinergic receptor affected the spontaneous eyeblink rate. We also revealed that the right angular gyrus is involved in generation of the spontaneous eyeblinks.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 6 results) Presentation (11 results) (of which Invited: 6 results)

  • [Int'l Joint Research] ハートフォードシャ大学(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The Right Angular Gyrus Controls Spontaneous Eyeblink Rate: A Combined Structural MRI and TMS Study2017

    • Author(s)
      Nakano T
    • Journal Title

      Cortex

      Volume: 88 Pages: 186-191

    • DOI

      10.1016/j.cortex.2016.12.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Short-latency allocentric control of saccadic eye movements2017

    • Author(s)
      Chakrabarty M, Nakano T, Kitazawa S
    • Journal Title

      Journal of Neurophysiology

      Volume: 117 Issue: 1 Pages: 376-387

    • DOI

      10.1152/jn.00451.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Blink and you'll miss it: the role of blinking in the perception of magic tricks2016

    • Author(s)
      Wiseman R.J. & Nakano T
    • Journal Title

      PeerJ

      Volume: e1873 Pages: 1873-1873

    • DOI

      10.7717/peerj.1873

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eyeblink Synchrony in Multimodal Human-Android Interaction2016

    • Author(s)
      Tatsukawa K, Nakano T, Ishiguro H & Yoshikawa Y
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 39718-39718

    • DOI

      10.1038/srep39718

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automatic representation of a visual stimulus relative to a background in the right precuneus2015

    • Author(s)
      Uchimura M, Nakano T, Morito Y, Ando H & Kitazawa S
    • Journal Title

      European Journal of Neuroscience

      Volume: 42 Issue: 1 Pages: 1651-1659

    • DOI

      10.1111/ejn.12935

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates.2015

    • Author(s)
      Nakano, T., Kuriyama, C., Himichi, T., & Nomura, M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8658-8658

    • DOI

      10.1038/srep08658

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the left insula in the ecological validity of the human voice2015

    • Author(s)
      Tamura Y, Kuriki S. & Nakano T.
    • Journal Title

      Scientific Reports 5

      Volume: 8799 Issue: 1

    • DOI

      10.1038/srep08799

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Blink-related dynamic switching between internal and external orienting networks while viewing videos.2015

    • Author(s)
      Nakano T.
    • Journal Title

      Neuroscience Research

      Volume: Mar. Pages: 54-58

    • DOI

      10.1016/j.neures.2015.02.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cortical networks for face perception in two-month-old infants2014

    • Author(s)
      Nakano T, Nakatani K.
    • Journal Title

      Proceedings of the Royal Society B Biological Sciences

      Volume: 281 Issue: 1793 Pages: 20141468-20141468

    • DOI

      10.1098/rspb.2014.1468

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Information processing in the human brain revealed by eyeblink2014

    • Author(s)
      Nakano T
    • Journal Title

      Brain and Nerve

      Volume: 66 Pages: 7-14

    • NAID

      40019947716

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Blink-related momentary activation of the default mode network while viewing videos2013

    • Author(s)
      Nakano T, Kato M, Morito Y, Itoi S, Kitazawa S.
    • Journal Title

      Proceedings of National Academy of Sciences

      Volume: 110 Pages: 702-706

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 瞬きにより明らかになったデフォルト・モード・ネットワークの新たな役割2013

    • Author(s)
      中野珠実
    • Journal Title

      生理心理学と精神生理学

      Volume: 31 Pages: 19-26

    • NAID

      130004876233

    • Related Report
      2013 Annual Research Report
  • [Presentation] 瞬きから探る脳内情報処理機構2016

    • Author(s)
      中野珠実
    • Organizer
      視覚フォーラム
    • Place of Presentation
      CiNet(大阪府吹田市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The neural mechanisms underlying interpersonal blink synchrony2016

    • Author(s)
      中野珠実
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] A novel utility of allocentric coordinates for controlling saccadic eye movements2015

    • Author(s)
      Mrinmoy Chakrabarty, Tamami Nakano, Shigeru Kitazawa
    • Organizer
      Neuro2015
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Automatic discrimination of accents by native dialect speakers: a behavioral and mismatch negativity study2015

    • Author(s)
      Abe Mayuka, Tamami Nakano, Shigeru Kitazawa
    • Organizer
      Neuro2015
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates2015

    • Author(s)
      中野珠実
    • Organizer
      日本生理学会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自発性瞬目の機能的役割とその神経機構2014

    • Author(s)
      中野珠実
    • Organizer
      電機情報通信学会HIP
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 瞬きの同期現象とその神経メカニズム2014

    • Author(s)
      中野珠実
    • Organizer
      日本心理学会第78回大会
    • Place of Presentation
      同志社大学今出川キャンパス, 京都市
    • Year and Date
      2014-09-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 瞬きから探る脳内情報処理機構

    • Author(s)
      中野珠実
    • Organizer
      日本心理学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 瞬きから探る脳内情報処理機構

    • Author(s)
      中野珠実
    • Organizer
      日本認知科学学会冬のワークショップ
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 瞬きから探る脳内情報処理機構

    • Author(s)
      中野珠実
    • Organizer
      難病神経セミナー
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 瞬きから探る脳内情報処理機構

    • Author(s)
      中野珠実
    • Organizer
      生理研社会性研究会
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-21   Modified: 2022-01-31  

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