Dielectrophoretic characterization and Identification of leukemia cells

• Project/Area Number: 25700025
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Soft computing
• Research Institution: Fuzzy Logic Systems Institute
• Principal Investigator: EGUCHI Masanori 一般財団法人ファジィシステム研究所, 研究部, 主任研究員 (60613594)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 誘電泳動 / エレクトロローテーション / 細胞計測 / マイクロ・ナノデバイス / ソフトコンピューティング

Outline of Final Research Achievements

We developed an electrorotation microwell array for high-throughput dielectric characterization of leukemia cells. The device consists of a microwell array and electrorotation chip. The practicality of the device was evaluated using tumor cells. The tumor cells were captured single cells in the microwells and measured electrorotation spectrum, which reflects its dielectric properties.

Research Products

• [Journal Article] Design of Electrode Shape for Measuring Dielectrophoretic Force at High Frequency Bands (2015)
  • Author(s): Masanori Eguchi, Futoshi Kuroki, Hiroko Imasato, and Takeshi Yamakawa
  • Journal Title: Reseach Activities of Investigative Committee on “Innovative Electromagnetic Technologies and Their Applied Developments" Volume: 1 Pages: 47-51
  • Acknowledgement Compliant
• [Presentation] 誘電特性の違いに基づいた細胞分離に関する研究 (2015)
  • Author(s): 江口 正徳, 今里浩子, 山川 烈
  • Organizer: 化学とマイクロ・ナノシステム学会第３２回研究会
  • Place of Presentation: 北九州国際会議場（福岡県・北九州市）
  • Year and Date: 2015-11-26
• [Presentation] Consideration on Mounting Structure for MEMS Switch at 60 GHz Band (2015)
  • Author(s): Kengo Nakajima, Futoshi Kuroki, Masanori Eguchi, and Takeshi Yamakawa
  • Organizer: Thailand-Japan MicroWave 2015
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2015-08-05
  • Int'l Joint Research
• [Presentation] Consideration on Grounded Coplanar Waveguide for RF-MEMS Integration (2015)
  • Author(s): Futoshi Kuroki, Kengo Nakajima, Masanori Eguchi, and Takeshi Yamakawa
  • Organizer: IEEE International Symposium on Antennas and Propagation and North American Radio Science Meeting
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2015-07-19
  • Int'l Joint Research
• [Presentation] 60GHz 帯 MEMS スイッチの実装に関する考察 (2015)
  • Author(s): 中島 健吾, 黒木 太司, 江口 正徳, 山川 烈
  • Organizer: 電子情報通信学会マイクロ波研究会
  • Place of Presentation: 機械振興会館（東京都・港区）
  • Year and Date: 2015-04-16
• [Presentation] Design and Evaluation of Electrode for Dielectrophoretic Characterization of Blood Cells (2015)
  • Author(s): Masanori Eguchi, Futoshi Kuroki, Hiroko Imasato, and Takeshi Yamakawa
  • Organizer: The 2015 IEEE Topical Conference on Bio-medical Wireless Technologies
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-01-25 – 2015-01-28
• [Presentation] Numerical and Experimental Approach on Separation of Cells Using Dielectrophoresis for Early Detection of Leukemic Disease at High Frequency Bands (2014)
  • Author(s): Futoshi Kuroki, Ayumu Akashi, Masanori Eguchi, and Takeshi Yamakawa
  • Organizer: The 44th European Microwave Conference
  • Place of Presentation: Rome Italy
  • Year and Date: 2014-10-06 – 2014-10-09
• [Presentation] Microwave Technologies for Biomedical Systems (2014)
  • Author(s): Masanori Eguchi
  • Organizer: The 3rd Smart City Workshop in Chennai
  • Place of Presentation: Chennai, India
  • Year and Date: 2014-09-11 – 2014-09-12
  • Invited
• [Presentation] Design of Ceiling Electrode for Cell Separation using Positive Dielectrophoresis and Inclined Gravity (2014)
  • Author(s): Masanori Eguchi, Futoshi Kuroki, Hiroko Imasato and Takeshi Yamakawa
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Hawaii, U.S.A
• [Presentation] 誘電泳動と進行波電界を用いた血液細胞の分離
  • Author(s): 江口 正徳, 山川 烈
  • Organizer: 電子情報通信学会マイクロ波研究会
  • Place of Presentation: 名古屋（愛知）
• [Remarks] 江口 正徳 一般財団法人ファジィシステム研究所
  • URL: http://flsi.cird.or.jp/personal_page/eguchi/index.html
• [Remarks] 江口 正徳 一般財団法人ファジィシステム研究所
  • URL: http://flsi.cird.or.jp/personal_page/eguchi/index.html