| Budget Amount *help |
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
In this study, we focused on a mechano-feedback at an intercellular adhesion machinery. At cellular-to-tissue level, we constructed a mathematical model expressing the feedback, and performed simulations on a growing spheroid-like tissue. These simulations revealed that continuous modifications through mechano-feedback are necessary for maintaining a smooth apical surface. At molecular level, we constructed a physical model for explaining actin-based mechano-sensing that is one of necessary components at the mechano-feedback. The model captured the qualitative and quantitative responses of actin-binding proteins to the forces, as observed experimentally. We theoretically suggested that actin-binding proteins can show different kinetic responses even to the same mechanical signal (tension).
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