Simulation on tissue formation through intercellular interaction
| Project/Area Number |
25702025
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
Inoue Yasuhiro 京都大学, 再生医科学研究所, 准教授 (80442929)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 細胞間相互作用 / メカノフィードバック / メカノセンシング / 数理モデル / 形態形成 / 細胞収縮 |
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| Outline of Final Research Achievements |
In this study, we focused on a mechano-feedback at an intercellular adhesion machinery. At cellular-to-tissue level, we constructed a mathematical model expressing the feedback, and performed simulations on a growing spheroid-like tissue. These simulations revealed that continuous modifications through mechano-feedback are necessary for maintaining a smooth apical surface. At molecular level, we constructed a physical model for explaining actin-based mechano-sensing that is one of necessary components at the mechano-feedback. The model captured the qualitative and quantitative responses of actin-binding proteins to the forces, as observed experimentally. We theoretically suggested that actin-binding proteins can show different kinetic responses even to the same mechanical signal (tension).
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Report
(4 results)
Research Products
(13 results)
