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Efficacy, treatment mechanism, and neurological basis of unified protocol of cognitive behavior therapy for emotional disorders

Research Project

Project/Area Number 25705018
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Clinical psychology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Ito Masaya  国立研究開発法人国立精神・神経医療研究センター, 認知行動療法センター, 室長 (20510382)

Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsうつ病 / 不安症 / 認知行動療法 / 統一プロトコル / 神経基盤 / 治療機序 / 診断横断 / 感情 / 感情障害 / 脳画像 / うつ / 不安 / 不安障害 / 感情調整
Outline of Final Research Achievements

The unified protocol for the transdiagnostic treatment of emotional disorders is a promising treatment approach that could be applicable to a broad range of mental disorders, including depressive, anxiety, trauma-related, and obsessive-compulsive disorders. However, no randomized controlled trial has been conducted to verify the efficacy of the unified protocol on the heterogeneous clinical population with depressive and anxiety disorders. The trial was designed as a single-center, assessor-blinded, randomized, 20-week, parallel-group superiority study in order to compare the efficacy of the combination of unified protocol and treatment-as-usual versus waiting-list with treatment-as-usual for patients with depressive and/or anxiety disorders. The primary outcome was depression at 21 weeks, assessed by the 17-item version of the GRID-Hamilton Rating Scale for Depression.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 4 results,  Open Access: 2 results) Presentation (8 results) (of which Invited: 1 results) Book (4 results) Remarks (3 results)

  • [Int'l Joint Research] ボストン大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Boston University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Boston University(米国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Reliability and Validity of the Japanese Version of the Emotion Regulation Skills Questionnaire.2016

    • Author(s)
      Fujisato, H., Ito, M., Takebayashi, Y., Hosogoshi, H., Kato N., Nakajima, S., Miyamae, M., Oe, Y., Usami, S., Kanie, A., Horikoshi, M., Berking, M.
    • Journal Title

      Journal of Affective Disorders

      Volume: 208 Pages: 145-152

    • DOI

      10.1016/j.jad.2016.08.064

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Japan Unified Protocol Clinical Trial for Depressive and Anxiety Disorders (JUNP study): study protocol for a randomized controlled trial.2016

    • Author(s)
      Ito M, Okumura Y, Horikoshi M, Kato N, Oe Y, Miyamae M, Hirabayashi N, Kanie A, Nakagawa A, Ono Y
    • Journal Title

      BMC Psychiatry

      Volume: 16(1) Issue: 1 Pages: 71-71

    • DOI

      10.1186/s12888-016-0779-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transdiagnostic and Transcultural: Pilot Study of Unified Protocol for Depressive and Anxiety Disorders in Japan.2016

    • Author(s)
      Ito, M., M. Horikoshi, N. Kato, Y. Oe, H. Fujisato, S. Nakajima, A. Kanie, M. Miyamae, Y. Takebayashi, R. Horita, M. Usuki, A. Nakagawa and Y. Ono
    • Journal Title

      Behavior Therapy

      Volume: 47 Issue: 3 Pages: 416-430

    • DOI

      10.1016/j.beth.2016.02.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Assessing Depression Related Severity and Functional Impairment: The Overall Depression Severity and Impairment Scale (ODSIS)2015

    • Author(s)
      Masaya Ito , Kate H. Bentley, Yuki Oe, Shun Nakajima, Hiroko Fujisato, Noriko Kato, Mitsuhiro Miyamae, Ayako Kanie, Masaru Horikoshi, David H. Barlow
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 4 Pages: e0122969-e0122969

    • DOI

      10.1371/journal.pone.0122969

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Validity and clinical interpretability of Overall Anxiety Severity And Impairment Scale (OASIS).2015

    • Author(s)
      Ito M, Oe Y, Kato N, Nakajima S, Fujisato H, Miyamae M, Kanie A, Horikoshi M, Norman SB.
    • Journal Title

      Journal of Affective Disorders

      Volume: 170 Pages: 217-224

    • DOI

      10.1016/j.jad.2014.08.045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 心的外傷後成長のプロセスと臨床家ができること2014

    • Author(s)
      伊藤正哉
    • Journal Title

      最新精神医学

      Volume: 19 Pages: 127-134

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 不安障害/うつ病性障害に対する新しい認知行動療法の潮流─診断横断的認知行動療法2013

    • Author(s)
      中島俊、伊藤正哉、加藤典子、堀田亮、藤里紘子、大江悠樹、宮前光宏、蟹江絢子、中川敦夫、堀越勝、大野裕
    • Journal Title

      精神医学

      Volume: 55 Pages: 1145-1154

    • NAID

      40019917338

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 不安やうつのCBTを求める成人患者が発達障がいの特徴を伴う場合:感情調整不全に注目した創意工夫2014

    • Author(s)
      伊藤正哉・加藤典子・大江悠樹・藤里紘子・中島俊・蟹江絢子・宮前光弘・堀田亮・堀越勝
    • Organizer
      日本認知・行動療法学会第40回大会
    • Place of Presentation
      日本、富山、富山国際会議場、205
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 感情が大事:曝露療法としての統一プロトコル2014

    • Author(s)
      伊藤正哉・中島俊・加藤典子・藤里紘子・蟹江絢子・大江悠樹・宮前光弘・堀田亮・堀越勝
    • Organizer
      日本認知・行動療法学会第40回大会
    • Place of Presentation
      日本、富山、富山国際会議場、204
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Emotion Regulation Skill Questionnaire日本語版作成及び信頼性・妥当性の検討2014

    • Author(s)
      藤里紘子・伊藤正哉・加藤典子・中島俊・宮前光宏・大江悠樹・蟹江絢子・細越寛樹・堀越勝
    • Organizer
      第14回日本認知療法学会
    • Place of Presentation
      日本、大阪、大阪国際会議場、1009
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 曝露の導入とその効果増強2014

    • Author(s)
      加藤典子・伊藤正哉・松岡豊・堀越勝
    • Organizer
      第14回日本認知療法学会
    • Place of Presentation
      日本、大阪、大阪国際会議場、1005
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 不安とうつに対する診断横断的治療のための統一プロトコル2014

    • Author(s)
      堀越勝・伊藤正哉
    • Organizer
      第14回日本認知療法学会
    • Place of Presentation
      日本、大阪、大阪国際会議場、1003
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CBTにおける診断横断アプローチは何をもたらすか2013

    • Author(s)
      伊藤正哉
    • Organizer
      第13回日本認知療法学会
    • Place of Presentation
      東京 帝京平成大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統一プロトコルは何をもたらすか2013

    • Author(s)
      伊藤正哉
    • Organizer
      第13回日本認知療法学会
    • Place of Presentation
      東京 帝京平成大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 不安を伴ううつ病に対する診断横断的な認知行動療法:感情調整に注目して2013

    • Author(s)
      伊藤正哉
    • Organizer
      第13回日本認知療法学会
    • Place of Presentation
      東京 帝京平成大学
    • Related Report
      2013 Annual Research Report
  • [Book] Applications of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (Chapter 16, Cross-cultural Applications of the Unified Protocol: Examples from Japan and Colombia)2017

    • Author(s)
      David H. Barlow and Todd Farchione (Ed), Amantia Ametaj, Nina Wong Sarver, Obianujunwa Anakwenze, Masaya Ito, Michel Ratner and Ramya Potluri(Author of Chapter 16)
    • Total Pages
      376
    • Publisher
      Oxford University Press
    • Related Report
      2017 Annual Research Report
  • [Book] Applications of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders2017

    • Author(s)
      Ametaj, A.A., Wong-Sarver, N., Anakwenze, O., Ito, M., Rattner Castro, M., & Potluri, S
    • Publisher
      Oxford University Press.
    • Related Report
      2016 Annual Research Report
  • [Book] 不安とうつの統一プロトコル バーロウ教授によるクリニカルデモンストレーション2014

    • Author(s)
      伊藤正哉・堀越勝(監修)デイビッド・バーロウ(講演)
    • Total Pages
      160
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] エモーション・フォーカスト・セラピー入門2013

    • Author(s)
      レスリー・グリーンバーグ著、岩壁茂・伊藤正哉・細越寛樹
    • Total Pages
      207
    • Publisher
      金剛出版
    • Related Report
      2013 Annual Research Report
  • [Remarks] うつと不安についての認知行動療法

    • URL

      http://cbt.ncnp.go.jp/cbt/trial_up

    • Related Report
      2017 Annual Research Report
  • [Remarks] 不安とうつへの認知行動療法の統一プロトコル

    • URL

      http://cbt.ncnp.go.jp/research/archives/5

    • Related Report
      2016 Annual Research Report
  • [Remarks] 感情障害への統一プロトコル

    • URL

      http://www.ncnp.go.jp/cbt/study/study02.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2022-02-16  

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