Start-up of "Cell Thermodynamics": Studies on thermal properties and signaling in single living cells.
| Project/Area Number |
25707035
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Jikei University School of Medicine (2015)
Waseda University |
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Principal Investigator |
Oyama Kotaro 東京慈恵会医科大学, 医学部, 特別研究員 (70632131)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Keywords | 細胞熱力学 / 温度測定 / 蛍光イメージング / 熱物性 / 温度感受性 / 神経細胞 / ブレブ / 熱伝導 / 単一細胞 / 熱伝導率 / 細胞熱物性 |
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| Outline of Final Research Achievements |
How does single living cell generate, sense, and efficiently use local changes in temperature? To answer the question, here we started the research area on “Cell Thermodynamics”. In this study, we analyzed heat transfer in single living cells. We also clarified temperature-sensitivities in various cells, such as directional bleb formation of cancer cells under local temperature gradient and neurite outgrowth triggered by microheating. These results provided us valuable information on thermal signaling at single-cell level.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Directional bleb formation in spherical cells under temperature gradient2015
Author(s)
Oyama, K.,* Arai, T., Isaka, A., Sekiguchi, T., Itoh, H., Seto, Y., Miyazaki, M., Itabashi, T., Ohki, T., Suzuki, M.* and Ishiwata, S.* (Corresponding authors)
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Journal Title
Biophys. J.
Volume: 109
Issue: 2
Pages: 355-364
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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