Exploring the dynamics and structure of the auditory system in fruit flies

• Project/Area Number: 25710001
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Nagoya University
• Principal Investigator: Kamikouchi Azusa 名古屋大学, 理学(系)研究科(研究院), 教授 (00525264)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
• Keywords: 聴覚情報処理 / 聴覚神経回路 / 神経応答 / 神経活動記録

Outline of Final Research Achievements

To explore the neural mechanism how the brain discriminates acoustic information, we have been using the fruit fly as an excellent model animal. To further develop the research of the auditory system using fruit flies, we mapped the auditory neural circuit in the fly brain at the single-cell level. By doing so we established a comprehensive map of the central auditory neural circuits, which would serve a basic knowledge to analyze the mechanism of auditory information processing in the brain in general.

Research Products

• [Journal Article] Organization of projection neurons and local neurons of the primary auditory center in the fruit fly Drosophila melanogaster. (2016)
  • Author(s): Matsuo E, Seki H, Asai T, Morimoto T, Miyakawa H, Ito K, Kamikouchi A
  • Journal Title: The Journal of comparative neurology Volume: 524 Issue: 6 Pages: 1099-1164
  • DOI: 10.1002/cne.23972
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The nutrient-responsive hormone CCHamide-2 controls growth by regulating insulin-like peptides in the brain of Drosophila melanogaster (2015)
  • Author(s): Sano H, Nakamur A, Texada M, Truma J, Ishimoto H, Kamikouchi A, Nibu Y, Kume K, Ida T, Kojima M
  • Journal Title: PLoS Genetics Volume: 11 Issue: 5 Pages: 1-26
  • DOI: 10.1371/journal.pgen.1005209
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Auditory system of fruit flies (2015)
  • Author(s): Ishikawa Y, Kamikouchi A
  • Journal Title: Hearing research Volume: In Press Pages: 1-8
  • DOI: 10.1016/j.heares.2015.10.017
  • NAID: 120005868241
  • Peer Reviewed
• [Journal Article] Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston’s organ of the fruit fly. (2014)
  • Author(s): Matsuo E, Yamada D, Ishikawa Y, Asai T, Ishimoto H, Kamikouchi A
  • Journal Title: Frontiers in Physiology Volume: 5 Pages: 179-179
  • DOI: 10.3389/fphys.2014.00179
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Plasticity in the auditory behavior of fruit flies (2016)
  • Author(s): N. Morimoto, A. Kamikouchi
  • Organizer: 2016 Association for Research in Otolaryngology MidWinter Meeting
  • Place of Presentation: Ｓａｎ Ｄｉｅｇｏ，ＣＡ，ＵＳＡ
  • Year and Date: 2016-02-20
  • Int'l Joint Research
• [Presentation] 異性への「好み」の急速な進化をもたらす神経基盤 (2015)
  • Author(s): 石川由希、上川内あづさ、山元大輔
  • Organizer: 日本進化学会第17回大会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-20
• [Presentation] Organization of antennal mechanosensory neurons for high-frequency sound in fruit flies (2015)
  • Author(s): A. Kamikouchi, N. Okamoto, M. Nakamura, E. Matsuo, Y. Ishikawa
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
  • Int'l Joint Research
• [Presentation] Auditory neural pathways in the fly brain (2015)
  • Author(s): Azusa Kamikouchi
  • Organizer: 3rd Asia-Pacific Drosophila Research Conference(APDRC)
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] Neuronal encoding of sound and gravity in the fruit fly (2015)
  • Author(s): Azusa Kamikouchi
  • Organizer: 2015 ARO Midwinter Meeting
  • Place of Presentation: ボルチモア
  • Year and Date: 2015-02-21
  • Int'l Joint Research / Invited
• [Presentation] Species Specificity of Male Auditory Response in Drosophila (2014)
  • Author(s): Yuki ISHIKAWA, Yusuke YONEYAMA, Azusa KAMIKOUCHI
  • Organizer: Neurofly2014
  • Place of Presentation: ギリシャ
  • Year and Date: 2014-10-08
  • Int'l Joint Research
• [Presentation] Auditory Neural Circuit in the Fly Brain (2014)
  • Author(s): Eriko Matsuo, Haruyoshi Seki, Takako Morimoto, Kei Ito, Azusa Kamikouchi
  • Organizer: Neurofly2014
  • Place of Presentation: ギリシャ
  • Year and Date: 2014-10-08
  • Int'l Joint Research
• [Presentation] Plasticity in the auditory behavior of the fruit fly (2014)
  • Author(s): Nao Morimoto, Azusa Kamikouchi
  • Organizer: International Congress of Neuroethology
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-29
  • Int'l Joint Research
• [Presentation] Neuronal Mechanisms Underlying Species Specificity of Mating Preference (2014)
  • Author(s): Yuki Ishikawa, Azusa Kamikouchi, Daisuke Yamamoto
  • Organizer: 11th Japanase Drosophila Research Conference
  • Place of Presentation: 金沢
  • Year and Date: 2014-06-04
• [Book] Auditory Transduction. In: Insect hearing (Eds: Pollack GS, Mason AC, Popper AN, Fay RR) (2016)
  • Author(s): Eberl DF, Kamikouchi A, Albert JT
  • Total Pages: 262
  • Publisher: Springer
• [Book] Hearing in Drosophila. In: Insect hearing (Eds: Pollack GS, Mason AC, Popper AN, Fay RR) (2016)
  • Author(s): Kamikouchi A, Ishikawa Y
  • Total Pages: 262
  • Publisher: Springer
• [Book] 動物行動の分子生物学 (新・生命科学シリーズ) (2014)
  • Author(s): 久保 健雄, 上川内 あづさ, 竹内 秀明 , 奥山 輝大
  • Total Pages: 179
  • Publisher: 久保 健雄, 上川内 あづさ, 竹内 秀明 , 奥山 輝大