Investigation of angiogenesis mechanism after central nervous system injury
Project/Area Number |
25710006
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Osaka University |
Principal Investigator |
Muramatsu Rieko 大阪大学, 医学(系)研究科(研究院), 准教授 (90536880)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | 軸索 / 血管 / 多発性硬化症 / 細胞増殖 / 神経細胞死 / 血管新生 / 神経細胞 / 炎症 / 脳 |
Outline of Final Research Achievements |
Injury and inflammation mediate disruption of neuronal network. Because disruption of neuronal network is involved in neuronal dysfunction, recovery from neuronal dysfunction is considered to require reconstruction of disrupted neuronal network after injury. Although the repair mechanism of neuronal network has been unknown, previous our study suggested that neovessels formed though inflammation promotes rewiring of neuronal network in damaged central nervous system (CNS). In the present study, we investigated the mechanism of neovessel formation which is crucial for rewiring of CNS network. We found that degeneration of neuronal network precedes angiogenesis after CNS inflammation. We tried to identify the factor which is released from degenerating neuron that promotes angiogenesis, and we succeeded to identify the key factor that promotes proliferation of vascular endothelial cells.
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Report
(4 results)
Research Products
(9 results)