Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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Outline of Final Research Achievements |
I developed cell-penetrating peptides (CPPs) with alpha,alpha-disubstituted alpha-amino acids (dAAs), which are one of the unnatural amino acids. Introduction of dAAs into the peptides stabilized their secondary structures as a helix even in aqueous solution. The dAAs-containing peptides showed high cell-penetrating ability compared to conventional CPPs and delivered plsmid DNA into the cultured cells efficiently.
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