2016 Fiscal Year Final Research Report
Development of cell-penetrating peptides and their application as DDS carriers
Project/Area Number |
25713008
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Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Drug development chemistry
|
Research Institution | Nagasaki University |
Principal Investigator |
OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | ペプチド / ドラッグデリバリーシステム / 非天然型アミノ酸 / コンフォメーション |
Outline of Final Research Achievements |
I developed cell-penetrating peptides (CPPs) with alpha,alpha-disubstituted alpha-amino acids (dAAs), which are one of the unnatural amino acids. Introduction of dAAs into the peptides stabilized their secondary structures as a helix even in aqueous solution. The dAAs-containing peptides showed high cell-penetrating ability compared to conventional CPPs and delivered plsmid DNA into the cultured cells efficiently.
|
Free Research Field |
創薬化学
|