Development of cell-penetrating peptides and their application as DDS carriers
Project/Area Number |
25713008
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Drug development chemistry
|
Research Institution | Nagasaki University |
Principal Investigator |
OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
|
Keywords | ペプチド / ドラッグデリバリーシステム / 非天然型アミノ酸 / コンフォメーション / 膜透過性ペプチド / 有機化学 / 薬学 / バイオテクノロジー |
Outline of Final Research Achievements |
I developed cell-penetrating peptides (CPPs) with alpha,alpha-disubstituted alpha-amino acids (dAAs), which are one of the unnatural amino acids. Introduction of dAAs into the peptides stabilized their secondary structures as a helix even in aqueous solution. The dAAs-containing peptides showed high cell-penetrating ability compared to conventional CPPs and delivered plsmid DNA into the cultured cells efficiently.
|
Report
(5 results)
Research Products
(31 results)