Elucidation of mechanisms of NKT cell mediated host defense against Streptococcus pneumoniae infection

• Project/Area Number: 25713038
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Kinjo Yuki 国立感染症研究所, その他部局等, 室長 (20570831)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000); Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 肺炎球菌 / NKT細胞 / 感染症 / 免疫学 / 内科

Outline of Final Research Achievements

Pneumonia is the third leading cause of death in Japan and Streptococcus pneumoniae (Pneumococcus) is the leading causative bacterium of pneumonia. To elucidate the mechanisms of host defense against Streptococcus pneumoniae in the early phase of infection, we studied a function of a lymphocyte called NKT cell. Mouse deficient for a subpopulation of NKT cell exhibited enhanced clearance of bacteria from lungs after Streptococcus pneumoniae infection. These mice also showed the improved outcome of post-influenza pneumococcal infection. These results suggest that this subpopulation of NKT cell may play a regulatory role on the host defense against Streptococcus pneumoniae infection.

Research Products

• [Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae (2016)
  • Author(s): Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
  • Journal Title: BMC Immunol Volume: 17 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s12865-015-0139-3
  • Peer Reviewed / Open Access
• [Journal Article] Human CD4- CD8- invariant natural killer T cells promote IgG secretion from B cells stimulated by cross-linking of their antigen receptors (2016)
  • Author(s): Miyasaka T, Watanabe Y, Akahori Y, Miyamura N, Ishii K, Kinjo Y, Miyazaki Y, Liu T-Y, Uemura Y, Kawakami K.
  • Journal Title: World J Vaccines Volume: 6 Pages: 34-41
  • Peer Reviewed
• [Journal Article] 感染症とNKT細胞 (2015)
  • Author(s): 金城 雄樹, 水口 裕紀
  • Journal Title: 医学のあゆみ Volume: 254 Pages: 1175-1178
• [Journal Article] インバリアントNKT細胞による糖脂質抗原認識と細菌感染防御の関連 (2014)
  • Author(s): 金城 雄樹
  • Journal Title: Surgery Frontier Volume: 21 Pages: 46-51
• [Journal Article] 自然リンパ球 iNKT細胞 (2014)
  • Author(s): 金城 雄樹
  • Journal Title: 医学のあゆみ Volume: 251 Pages: 486-489
• [Journal Article] The role of invariant natural killer T cells in microbial immunity. (2013)
  • Author(s): Kinjo Y, Kitano N & Kronenberg M.
  • Journal Title: J. Infect. Chemother Volume: 19 Issue: 4 Pages: 560-570
  • DOI: 10.1007/s10156-013-0638-1
  • NAID: 10031194380
  • Peer Reviewed
• [Journal Article] 特集 注目されるNatural killer T （NKT）細胞 2. 感染防御に重要なNKT細胞 (2013)
  • Author(s): 金城雄樹
  • Journal Title: 血液フロンティア Volume: 23 Pages: 33-39
• [Presentation] NKT cell mediated protection against pneumococcal infection (2015)
  • Author(s): Yuki Kinjo, Makiko Nakahara, Yuki Mizuguchi, Yuina Izawa, Naoki Kitano, Kayo Ohkouchi, Keigo Ueno, Zhenyu Piao, Yukihiro Akeda, Yoshitsugu Miyazaki, Kazunori Oishi.
  • Organizer: CD1-MR1 2015
  • Place of Presentation: オーストラリア、ローン
  • Year and Date: 2015-11-15
• [Presentation] International symposium 3 「Bacterial cell component and host defense」. NKT cell mediated defense against Streptococcus pneumoniae infection. (2014)
  • Author(s): Yuki Kinjo
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: 東京
• [Presentation] iNKT細胞を介した肺炎球菌感染防御 (2014)
  • Author(s): 金城雄樹
  • Organizer: 糖鎖免疫2014
  • Place of Presentation: 東京
• [Presentation] 特別講演1. 感染免疫におけるiNKT細胞の役割. (2013)
  • Author(s): 金城雄樹
  • Organizer: 感染症研究グローバルネットワークフォーラム2013
  • Place of Presentation: 千葉
  • Invited