| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2013: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Outline of Final Research Achievements |
In this study, we investigated the functions of osteoclasts (OCs) from Fas-mutant MRL/lpr mice, murine model for rheumatoid arthritis (RA). In vitro and in vivo experiments showed hyperfunction of MRL/lpr OCs. Furthermore, the migratory response of MRL/lpr OC precursors to S1P was significantly enhanced. The hyper function of OCs in MRL/lpr mice play a potent role in the pathogenesis for RA with bone and cartilage destruction. Crosstalk between RANK/RANKL signaling and Fas/FasL signaling of OCs may regulate the differentiation and migratory function of OC precursors.
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