Construct a mathematical model for optimizing the glucocorticoid replacement in patients with adrenocortical insufficiency
| Project/Area Number |
25730179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
AOKI Sorama 東北薬科大学, 薬学部, 助手 (40584462)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ステロイド補充療法 / データマイニング / クッシング症候群 / 副腎不全 / 基本的検査 / ステロイド / パターン認識 / インフォマティクス / パターン認識手法 |
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| Outline of Final Research Achievements |
Using the self-organizing map which is one of the pattern recognition methods, we successfully constructed the model that can predict the lack of and the excess of the internal glucocorticoids, making use of a set of 13 routine tests ( γ-glutamyl trans peptitase [γ - GTP], lactate dehydrogenase [LDH], serum sodium [Na], serum potassium [K], serum chlorine [Cl], high density lipoprotein cholesterol [HDL-C], neutrophil count [Neut#], eosinophil count [Eosi#], lymphocyte counts [Lymp#], monocyte count [Mono#], red blood cell count [RBC], hemoglobin [Hg], hematocrit [HCT].
Furthermore, we quantitatively represented the effects of the internal glucocorticoids against the each of the routine tests by a simultaneous differential equation.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] Analyzing data of steroid replacement therapy after surgery for Cushing's syndrome by using the pattern recognition methods and mathematical modelling to assist appropriate steroid supplement2014
Author(s)
Kenichi Sato, Sorama Aoki, Masataka Kudo, Fumitoshi Satoh, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Ken Matsuda, Akira Sugawara, Katsumi Yoshida, and Sadayoshi Ito
Organizer
The 2014 International Conference on Brain Informatics and Health
Place of Presentation
Warsaw, Poland
Year and Date
2014-08-11 – 2014-08-14
Related Report
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