Effect of high-energy visible light on animal cells.
Project/Area Number |
25740018
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation and chemicals
|
Research Institution | Tamagawa University |
Principal Investigator |
SATO Kazuomi 玉川大学, 農学部, 准教授 (10554991)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | アポトーシス / 細胞死 / 可視光線 / 青色光 / ミトコンドリア / メラニン生成 / メラノーマ / ミトコンドリア膜電位 / 活性酸素 / ネクローシス |
Outline of Final Research Achievements |
The aim of the present work was to clarify the mechanism of cell death induced by visible light. Blue light induced mitochondrial membrane potential depolarization subsequent to elevation of intracellular superoxide production. Moreover, blue light induced cell surface exposure of phosphatidylserine. Mitochondrial membrane potential is an indicator of mitochondria-dependent apoptosis. Thus, blue light causes mitochondrial dysfunction and subsequent apoptosis.
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Report
(3 results)
Research Products
(7 results)