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Could citric acid be an effective food against plethora induced by hypoxemia in rats?

Research Project

Project/Area Number 25750054
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionShowa Women's University

Principal Investigator

WATANABE Nakamichi  昭和女子大学, 生活機構研究科, 准教授 (90365809)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsクエン酸 / 低酸素 / 多血症 / 低酸素曝露
Outline of Final Research Achievements

Plethora causes an increase in cerebral infarction owing to a drastic decrease in blood fluidity This study aimed to examine whether citric acid could be an effective food against plethora induced by hypoxemia in rats. Unfortunately, citric acid might not be an effective food. On the other hand, intake of citric acid was found to counteract the hypoxia-induced decrease in liver glycogen levels. Moreover, citric acid was found to have the potential to suppress inflammation in skeletal muscles. Therefore, citric acid might be effective against hypoxia.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Effects of Dietary Citric Acid on Metabolic Indicators and Gene Expression in the Skeletal Muscles of Fasted Mice2013

    • Author(s)
      Yurie Hara, Nakamichi Watanabe
    • Journal Title

      Food and Nutrition Sciences

      Volume: 11 Issue: 11 Pages: 1114-1119

    • DOI

      10.4236/fns.2013.411145

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 低酸素条件下で飼育したラットはどうなるのか2013

    • Author(s)
      原百合恵・渡辺睦行
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 多血症モデルラットの作製~呼吸器疾患に伴う多血症の食事療法確立に向けて~2013

    • Author(s)
      原百合恵・渡辺睦行
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      実践女子大学(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of dietary citric acid on energy metabolism of the skeletal muscles and liver in mice2013

    • Author(s)
      Yurie Hara, Nakamichi Watanabe
    • Organizer
      IUNS
    • Place of Presentation
      Granada Congress Centre (Granada, Spain)
    • Related Report
      2013 Research-status Report
  • [Presentation] 低酸素曝露に対する生体応答2013

    • Author(s)
      原百合恵・渡辺睦行
    • Organizer
      日本ヘモレオロジー学会
    • Place of Presentation
      獨協医科大学病院(栃木県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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