Screening of novel molecules that regulate the histone deacetylase activity from foods and development of nerve regeneration treatment
Project/Area Number |
25750059
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Yamanashi Gakuin University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | HDAC / アントシアニジン / 神経保護効果 / 神経突起伸長 / ヒストンアセチル化 / p53 / Hdac / p53 / ヒストン脱アセチル化酵素 / 神経突起伸長効果 / ポリフェノール類 / 脊髄損傷 |
Outline of Final Research Achievements |
We found that cyanidin and peonidin inhibited histone deacetylase (HDAC) and increased histone acetylation. Using a primary culture neuronal cells and SH-SY5Y cell lines to consider the effect on the neuronal cell protective effect and the neurite outgrowth. Cyanidin and peonidin protected SH-SY5Y cells from endoplasmic reticulum stress, and promoted neuronal outgrowth in primary cultured neuronal cells. Cyanidin and peonidin decreased CHOP expression and increased GAP-43 expression. On the other hand acetylated p53 localized to the nucleus. Our data suggests that the neuroprotection and neurite elongation by cyanidin and peonidin might be involved in acetylation of histone and p53.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS.2013
Author(s)
Hirano K, Ohgomori T, Kobayashi K, Tanaka F, Matsumoto T, Natori T, Matsuyama Y, Uchimura K, Sakamoto K, Takeuchi H, Hirakawa A, Suzumura A, Sobue G, Ishiguro N, Imagama S, Kadomatsu K.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury.2013
Author(s)
Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K.
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Journal Title
Neuroscience letters
Volume: 550
Pages: 150-155
Related Report
Peer Reviewed
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