Regulation of neuroinflammation by low-reactive level laser irradiation

• Project/Area Number: 25750169
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Yamato Masanori 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (50565778)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 近赤外レーザー / 脳内神経炎症 / エネルギー代謝 / 脳内炎症

Outline of Final Research Achievements

Low-level laser therapy (LLLT) has recently been used as a new anti-inflammatory clinical therapy and is associated with few, if any, side effects. In the present study, we clarified that externally directed LLLT could penetrate into brain and that LLLT slightly suppressed the expressions of inflammatory cytokines in rat brain. Next, metabolome analysis of brain showed that the changes in many metabolites related to energy production or neurotransmission were observed. Now we focus on the effect of LLLT on change of energy metabolism in the brain during neuroinflammation.

Research Products

• [Journal Article] Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. (2015)
  • Author(s): Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.
  • Journal Title: PLOS ONE Volume: 10(3) Issue: 3 Pages: e0120106-e0120106
  • DOI: 10.1371/journal.pone.0120106
  • Peer Reviewed / Open Access
• [Journal Article] Fatigue-like behavior following peripheral viral infection is likely triggered by neuroinflammation. (2015)
  • Author(s): Yamato, M. and Kataoka, Y.
  • Journal Title: Neural Regen. Res. Volume: 10 Issue: 2 Pages: 203-204
  • DOI: 10.4103/1673-5374.152369
  • Peer Reviewed / Open Access
• [Journal Article] Brain interleukin-1beta and the intrinsic receptor antagonist control peripheral toll-like receptor 3-mediated suppression of spontaneous activity in rats. (2014)
  • Author(s): Yamato, M., Tamura, Y., Eguchi, A., Watanabe, Y., and Kataoka, Y.,
  • Journal Title: PLOS ONE Volume: 9 Issue: 3 Pages: e90950-e90950
  • DOI: 10.1371/journal.pone.0090950
  • Peer Reviewed / Open Access
• [Journal Article] 近赤外低反応レベルレーザー照射による腎炎抑制効果 (2014)
  • Author(s): 大和正典、金田明、片岡洋祐
  • Journal Title: 日本レーザー医学会誌 Volume: 34 Pages: 402-405
  • NAID: 130005065160
  • Peer Reviewed
• [Journal Article] 生体への近赤外レーザー光照射と抗炎症効果 (2014)
  • Author(s): 片岡洋祐、大和正典、金田明
  • Journal Title: 光アライアンス Volume: 25 Pages: 13-17
  • Peer Reviewed
• [Journal Article] Neuroinflammation in animal models of fatigue. (2013)
  • Author(s): Kataoka, Y., Yamato, M., Miyashige, Y., Tamura, Y., and Cui, Y.
  • Journal Title: Adv. Neuroimmune Biol. Volume: 4 Issue: 4 Pages: 237-244
  • DOI: 10.3233/nib-130073
  • Peer Reviewed
• [Presentation] The relationship between neuroinflammation and changes in brain energy metabolism in prolonged suppression of spontaneous activity induced by monofluoroacetate, an inhibitor for TCA cycle (2015)
  • Author(s): Masanori Yamato, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuhisa Tamura, Asami Eguchi, and Yosky Kataoka
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸市・兵庫県
  • Year and Date: 2015-07-28
• [Presentation] エネルギー代謝の低下に着目した疲労動物モデルにおける脳内神経炎症の惹起 (2015)
  • Author(s): 大和 正典, 久米 慧嗣, 金 光華, 中野 真行, 江口 麻美, 田村 泰久, 片岡 洋祐
  • Organizer: 第11回日本疲労学会
  • Place of Presentation: 山口県総合保健会館・山口市・山口県
  • Year and Date: 2015-05-15
• [Presentation] 近赤外低反応レベルレーザー照射による腎炎抑制効果 (2015)
  • Author(s): 大和正典 ，金田 明，片岡洋祐
  • Organizer: レーザー学会学術講演会 第 3 5 回年次大会
  • Place of Presentation: 東海大学（東京）
  • Year and Date: 2015-01-11 – 2015-01-12
  • Invited
• [Presentation] Neuroinflammation is possibly involved in in prolonged suppression of rat spontaneous activity induced by monofluoroacetate, an inhibitor for TCA cycle (2014)
  • Author(s): Masanori Yamato, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuhisa Tamura, Asami Eguchi, and Yosky Kataoka
  • Organizer: Neuroscience 2014
  • Place of Presentation: Walter E. Washington Convention Center (Washington DC)
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Possible involvement of neuroinflammation in prolonged suppression of rat spontaneous activity by monofluoroacetate, an inhibitor for TCA cycle (2014)
  • Author(s): Masanori Yamato, Satoshi Kume, Guanghua Jin, Yukiharu Miyashige, Masayuki Nakano, Yasuhisa Tamura, Asami Eguchi, and Yosky Kataoka
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 近赤外低反応レベルレーザー照射による腎炎抑制効果 (2014)
  • Author(s): 大和正典、金田明、片岡洋祐
  • Organizer: 第26回日本レーザー治療学会学術集会・総会
  • Place of Presentation: ステーションコンファレンス万世橋（東京）
  • Year and Date: 2014-06-28 – 2014-06-29
• [Presentation] エネルギー代謝の低下に着目した疲労動物モデルの作製と評価 (2014)
  • Author(s): 大和正典, 久米慧嗣, 金光華, 宮繁志治, 中野真行, 江口麻美, 田村泰久, 片岡洋祐
  • Organizer: 第10回日本疲労学会総会・学術集会
  • Place of Presentation: コングレコンベンションセンター（大阪）
  • Year and Date: 2014-05-30 – 2014-05-31
• [Presentation] エネルギー代謝の低下に着目した疲労動物モデルの作製と評価 (2014)
  • Author(s): 大和正典、久米慧嗣、金光華、宮繁志治、中野真行、江口麻美、田村泰久、片岡洋祐
  • Organizer: 第10回日本疲労学会
  • Place of Presentation: コングレコンベンションセンター（大阪府大阪市）
• [Presentation] 近赤外低反応レベルレーザー照射による腎炎抑制効果 (2014)
  • Author(s): 大和正典、金田明、片岡洋祐
  • Organizer: 第26回日本レーザー治療学会
  • Place of Presentation: ステーションコンファレンス万世橋（東京都千代田区）
• [Presentation] Regulation of various cellular functions by low-reactive level near-infrared laser irradiation (2013)
  • Author(s): Masanori Yamato, Yasuhisa Tamura, Maki Katuhiro, Hiroshi Riquimaroux, Yosky Kataoka
  • Organizer: The 2013 International Conference on Brain and Health Infomatics
  • Place of Presentation: 前橋テルサ（群馬県前橋市）
• [Patent(Industrial Property Rights)] 炎症抑制方法、及び炎症抑制用光照射装置 (2014)
  • Inventor(s): 片岡洋祐、大和正典、竹田昂司、西口英二
  • Industrial Property Rights Holder: 片岡洋祐、大和正典、竹田昂司、西口英二
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-05-30
• [Patent(Industrial Property Rights)] 疲労のバイオマーカーおよびその利用 (2014)
  • Inventor(s): 片岡 洋祐, 久米 慧嗣, 大和 正典, 他6名
  • Industrial Property Rights Holder: 片岡 洋祐, 久米 慧嗣, 大和 正典, 他6名
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-08-29