| Project/Area Number |
25750170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Koshino Kazuhiro 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (90393206)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 動態解析 / 心筋血流量 / 入力関数 / 生理機能測定 |
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| Outline of Final Research Achievements |
The purpose of this study was to improve accuracy of less invasive estimation of input function for myocardial blood flow. Optimal condition for population based input function and one point arterial blood sampling was determined using individual input functions measured on 201TlCl and single photon emission computed tomography. For the population based input function, the minimum bias and a variation of percent difference of 3.9 ± 2.9 were obtained. Errors in regional myocardial blood flow using the technique were 0.7 ± 7.8 %. Global myocardial blood flow showed significant correlations with rate-pressure products, R2 = 0.303; p < 0.05. It was considered that the proposed technique provided hemodynamically reasonable values. Estimation of input functions using radioactivity concentration of arterial blood in descending aortas with corrections for signal mixture and partial volume effects showed underestimation of -9.0 ± 8.1 %. Further improvement was needed for the approach.
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