| Project/Area Number |
25750213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya City University |
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Principal Investigator |
ISHIDA Akimasa 名古屋市立大学, 医学(系)研究科(研究院), 助教 (20632607)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | リハビリテーション / 脳出血 / 内包 / CI療法 / 赤核 / 運動野 / 可塑的変化 / 機能回復 / 上肢機能 / 運動機能 / 神経可塑性 / 選択的経路遮断 / 皮質赤核路 / CIMT |
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| Outline of Final Research Achievements |
As constraint-induced movement therapy (CIMT) promotes functional recovery of impaired forelimb after hemiplegic strokes, including intracerebral hemorrhage (ICH), we challenged to determine the causal relationship between the CIMT-induced reorganization of the circuit and behavioral recovery after stroke.
We clarified the detailed and longitudinal reorganization of the ipsi-lesional motor cortex induced by CIMT after internal capsule hemorrhage in rats. Using the double-viral vector technique which induces pathway-selective blockade of the target pathway, we clearly revealed that the increased cortico-rubral axonal projections had causal linkage to the CIMT-induced recovery of forelimb reaching function. The present study demonstrates the cortico-rubral pathway is responsible circuits for the efficiency of CIMT. Our data will provide new insight into the underlying neural mechanisms of poststroke neurorehabilitative therapies.
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