Elucidation and its application of muscle hypertrophic mechanism for blood flow restricted training: Comparison between concentric and eccentric contraction.

• Project/Area Number: 25750288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Seirei Christopher University (2015); The University of Tokyo (2013-2014)
• Principal Investigator: Yasuda Tomohiro 聖隷クリストファー大学, 看護学部, 准教授 (20549604)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血流制限 / 筋力トレーニング / 筋収縮 / ディトレーニング / 筋収縮様式 / 脱トレーニング / 弾性バンド / 高齢者 / 短縮性筋活動 / 伸張性筋活動 / 筋肥大 / 筋力増加 / 低重量

Outline of Final Research Achievements

Our results show that
1) Increased muscle strength following 6 weeks of concentric blood flow restricted (BFR) exercise was well preserved at 6 weeks of detraining, which may be primarily related to muscle hypertrophy. 2) elastic band BFR training improves muscle cross-sectional area as well as maximal muscle strength but does not negatively affect arterial stiffness in older adults. 3) Increased muscle strength/size following 12 weeks of elastic band BFR training was well maintained with a low risk of arterial stiffness after 12 weeks of detraining in older women.

Research Products

• [Journal Article] Effects of detraining after blood flow restricted elastic band training on muscle adaptations and arterial stiffness in older adults. (2015)
  • Author(s): Yasuda T, Fukumura K, Iida H, Nakajima T.
  • Journal Title: SpringerPlus Volume: 4 Issue: 1 Pages: 348-348
  • DOI: 10.1186/s40064-015-1132-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effects of low-load, elastic band resistance training combined with blood flow restriction on muscle size and arterial stiffness in older adults. (2015)
  • Author(s): Yasuda T, Fukumura K, Uchida Y, Koshi H, Iida H, Masamune K, Yamasoba T, Sato Y, Nakajima T.
  • Journal Title: The Journals of Gerontology, Series A: Biological Sciences Volume: 印刷中 Issue: 8 Pages: 950-958
  • DOI: 10.1093/gerona/glu084
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of low-load resistance exercise to volitional exhaustion on muscle swelling: Comparison of blood flow restriction and non-blood flow restriction. (2015)
  • Author(s): Yasuda T, Fukumura K, Iida H, Nakajima T.
  • Journal Title: European Journal of Applied Physiology Volume: 115 Issue: 5 Pages: 919-926
  • DOI: 10.1007/s00421-014-3073-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of short-term detraining following blood flow restricted low-intensity resistance training on muscle size and strength. (2015)
  • Author(s): Yasuda T, Loenneke JP, Ogasawara R, Abe T.
  • Journal Title: Clinical Physiology and Functional Imaging Volume: 35 Issue: 1 Pages: 71-75
  • DOI: 10.1111/cpf.12165
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of detraining after blood flow restricted concentric or eccentric training on muscle size and strength (2015)
  • Author(s): Yasuda T, Loenneke JP, Thiebaud RS, Abe T.
  • Journal Title: Journal of Physiological Sciences Volume: 65 Issue: 1 Pages: 139-144
  • DOI: 10.1007/s12576-014-0345-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Muscle size and arterial stiffness after blood flow-restricted low-intensity resistance training in older adults. (2014)
  • Author(s): Yasuda Y, Fukumura K, Fukuda T, Uchida Y, Iida H, Meguro M, Sato Y, Yamasoba T, Nakajima T.
  • Journal Title: Scand J Med Sci Sports Volume: 24 Issue: 5 Pages: 799-806
  • DOI: 10.1111/sms.12087
  • Peer Reviewed
• [Journal Article] Effects of detraining after blood flow restricted low-intensity training on muscle size and strength in older adults (2014)
  • Author(s): Yasuda T, Fukumura K, Sato Y, Yamasoba T, Nakajima T
  • Journal Title: Aging Clinical and Experimental Research Volume: (in press) Issue: 5 Pages: 561-564
  • DOI: 10.1007/s40520-014-0208-0
  • Peer Reviewed
• [Journal Article] 疲労困憊に至る低強度レジスタンス運動がmuscle swellingへ及ぼす影響：血流制限と非血流制限の比較 (2014)
  • Author(s): 安田智洋、福田平、福村和也、内田祐介
  • Journal Title: デサントスポーツ科学 Volume: 35 Pages: 70-77
  • NAID: 120006475568
  • Acknowledgement Compliant
• [Journal Article] Effects of short-term detraining following blood flow restricted low-intensity resistance training on muscle size and strength. (2014)
  • Author(s): Yasuda T, Loenneke JP, Ogasawara R, Abe T.
  • Journal Title: Clinical Physiology and Functional Imaging Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 超音波Bモード法による下肢筋厚と体力テストとの関係 ～スポーツ健康科学実技Iにおける大学新入生男子を対象として～ (2014)
  • Author(s): 一川大輔、山崎享子、安田智洋
  • Journal Title: スポーツ健康科学紀要 Volume: 11 Pages: 1-10
• [Journal Article] 血流制限下のセラバンド・トレーニングが高齢者の筋肥大、筋力増加および安全性に及ぼす影響 (2014)
  • Author(s): 安田智洋、中島敏明
  • Journal Title: 健康医科学 Volume: 29 Pages: 120-127
  • NAID: 120006475565
• [Journal Article] Influence of continuous or intermittent blood flow restriction on muscle activation during low-intensity multiple sets of resistance exercise (2013)
  • Author(s): Yasuda T, Loenneke JP, Ogasawara R, Abe T.
  • Journal Title: Acta Physiologica Hungarica Volume: 100 Issue: 4 Pages: 419-426
  • DOI: 10.1556/aphysiol.100.2013.4.6
  • Peer Reviewed
• [Journal Article] Low-intensity kaatsu resistance exercises using an elastic band enhance muscle activation in patients with cardiovascular diseases (2013)
  • Author(s): Fukuda T, Yasuda T, Fukumura K, Iida H, Morita T, Sato Y, Nakajima.
  • Journal Title: International Journal of Kaatsu Training Research Volume: 9 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Cardiac rehabilitation increases exercise capacity with a reduction of oxidative stress. (2013)
  • Author(s): Fukuda T, Kurano M, Fukumura K, Yasuda T, Iida H, Morita T, Yamamoto Y, Takano N, Komuro I, Nakajima T.
  • Journal Title: Korean Circ J. Volume: 43 Issue: 7 Pages: 481-487
  • DOI: 10.4070/kcj.2013.43.7.481
  • Peer Reviewed
• [Journal Article] Effects of low-intensity, elastic band resistance exercise combined with blood flow restriction on muscle activation. (2013)
  • Author(s): Yasuda T, Fukumura K, Fukuda T, Iida H, Imuta H, Sato Y, Yamasoba T, Nakajima T.
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 印刷中 Issue: 1 Pages: 55-61
  • DOI: 10.1111/j.1600-0838.2012.01489.x
  • Peer Reviewed
• [Journal Article] Indirect markers of muscle damage induced by low-intensity blood flow restricted concentric or eccentric muscle action (2013)
  • Author(s): Thiebaud RS, Yasuda T, Loenneke JP, Abe T
  • Journal Title: Interventional Medicine and Applied Science Volume: 5(2) Issue: 2 Pages: 53-59
  • DOI: 10.1556/imas.5.2013.2.1
  • Peer Reviewed
• [Presentation] 健康長寿と運動（一生役立つ運動の知識） (2015)
  • Author(s): 安田智洋
  • Organizer: 日本医学協会（第２回健康講座）
  • Place of Presentation: 清瀬市商工協同組合
  • Year and Date: 2015-02-25
  • Invited
• [Presentation] 内部障害理学療法における身体機能評価としての筋厚評価の有用性 (2014)
  • Author(s): 福村和也、安田智洋、中島敏明
  • Organizer: 第１回日本呼吸・心血管・糖尿病理学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-21
• [Presentation] 健康測定における運動指導 (2014)
  • Author(s): 安田智洋
  • Organizer: 健康スポーツ医部会幹事会研修
  • Place of Presentation: 神奈川県医師会
  • Year and Date: 2014-11-20
  • Invited
• [Presentation] 高齢認知症患者に対する加圧トレーニングによる日常生活活動改善効果の検討 (2014)
  • Author(s): 金原賢児、森田敏宏、大澄清也、杉本慎平、福村和也、安田智洋、原湖南、中島敏明
  • Organizer: 第10回日本加圧トレーニング学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18 – 2014-10-19
• [Presentation] 加圧トレーニングが高齢者に及ぼす生体リスクの検証 (2014)
  • Author(s): 福村和也、安田智洋、飯田陽子、中島敏明
  • Organizer: 第10回日本加圧トレーニング学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18 – 2014-10-19
• [Presentation] 筋サイズと筋力に及ぼす脱トレーニングの影響：短縮性と伸張性の血流制限下低強度トレーニングの比較 (2014)
  • Author(s): 安田智洋、中島敏明
  • Organizer: 第69回 日本体力医学会
  • Place of Presentation: 長崎大学
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 疲労困憊に至る低強度レジスタンス運動がmuscle swellingへ及ぼす影響：血流制限と非血流制限の比較 (2014)
  • Author(s): 安田智洋、福村和也、中島敏明
  • Organizer: 第65回日本体育学会
  • Place of Presentation: 岩手大学
  • Year and Date: 2014-08-25 – 2014-08-28
• [Presentation] Skeletal muscle hypertrophy induced by novel KAATSU rehabilitation and prevention of sarcopenia (2014)
  • Author(s): Nakajima T, Yasuda T, Koide S, Sato Y, Kano Y.
  • Organizer: 19th World Congress on Heart Disease
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-07-25 – 2014-07-28
  • Invited
• [Presentation] 当院循環器内科病棟における集団運動療法の取り組み (2014)
  • Author(s): 菅原芳恵、福村和也、安田智洋、小松佐和子、桑原由衣、小武方希穂子、中島敏明、小室一成
  • Organizer: 第20回日本心臓リハビリテーション学会
  • Place of Presentation: 京都
  • Year and Date: 2014-07-19 – 2014-07-20
• [Presentation] 血流制限下のセラバンド・トレーニングと脱トレーニングが高齢者の筋サイズ、筋力と血管機能に及ぼす影響 (2014)
  • Author(s): 安田智洋、福村和也、飯田陽子、輿日登美、佐藤義昭、中島敏明
  • Organizer: 第20回日本心臓リハビリテーション学会
  • Place of Presentation: 京都
  • Year and Date: 2014-07-19 – 2014-07-20
• [Presentation] 血流制限下トレーニングは、骨格筋GLUT4及びMCT1タンパクの発現を亢進する：ラット加圧モデルによる検討 (2014)
  • Author(s): 中島敏明、安田智洋、小出誠一郎、佐藤義昭、狩野豊
  • Organizer: 第20回日本心臓リハビリテーション学会
  • Place of Presentation: 京都
  • Year and Date: 2014-07-19 – 2014-07-20
• [Presentation] Muscle size and arterial stiffness after blood flow-restricted elastic band resistance training in older adults. (2014)
  • Author(s): Yasuda T, Fukumura K, Uchida Y, Koshi H, Iida H, Masamune K, Yamasoba T, Sato Y, Nakajima T.
  • Organizer: 60th Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Orland, USA
  • Year and Date: 2014-05-27 – 2014-05-31
• [Presentation] Muscle size and arterial stiffness after blood flow-restricted elastic band resistance training in older adults. (2014)
  • Author(s): Yasuda T, Fukumura K, Uchida Y, Koshi H, Iida H, Masamune K, Yamasoba T, Sato Y, Nakajima T.
  • Organizer: 60th Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Orland、アメリカ
• [Presentation] Skeletal muscle hypertrophy induced by novel KAATSU rehabilitation and prevention of sarcopenia (2014)
  • Author(s): Nakajima T, Yasuda T, Koide S, Sato Y, Kano Y.
  • Organizer: 19th World Congress on Heart Disease
  • Place of Presentation: Boston、アメリカ
  • Invited
• [Presentation] 加圧トレーニングと骨格筋の適応 (2013)
  • Author(s): 安田智洋
  • Organizer: 第159回日本体力医学会関東地方会
  • Place of Presentation: 電気通信大学
  • Invited
• [Presentation] 加圧トレーニング介入によるサルコペニア予防・治療の可能性 (2013)
  • Author(s): 安田智洋
  • Organizer: 東大病院 22世紀医療センター公開セミナー
  • Place of Presentation: 東京大学
• [Presentation] サルコペニア対策としての加圧トレーニング (2013)
  • Author(s): 安田智洋
  • Organizer: 第8回日本加圧トレーニング学会総会
  • Place of Presentation: よみうりホール（東京）
  • Invited
• [Presentation] 長期ディトレーニングが加圧トレーニング後の筋力・筋サイズに及ぼす影響 (2013)
  • Author(s): 安田智洋、福村和也、中島敏明
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京慈恵医科大学
• [Presentation] 血流制限下の低強度筋力トレーニングが高齢者の筋サイズ、筋力、血管機能に及ぼす影響 (2013)
  • Author(s): 安田智洋、福村和也、福田平、内田祐介、飯田陽子、目黒美葉、佐藤義昭、中島敏明
  • Organizer: 第19回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 仙台国際センター
• [Presentation] Muscle size and arterial compliance after blood flow-restricted low-intensity resistance training in older adults. (2013)
  • Author(s): Yasuda T, Fukumura K, Fukuda T, Uchida Y, Iida H, Ohtsuka T, Chujo Y, Meguro M, Sato Y, Nakajima T.
  • Organizer: 60th Annual Meeting of the American College of Sports Medicine
  • Place of Presentation: Indianapolis、アメリカ
• [Presentation] Repetitive restriction of muscle blood flow enhances mTOR signaling pathways in a rat model. (2013)
  • Author(s): Nakajima T, Yasuda T, Koide S, Takano N, Sato Y, Kano Y.
  • Organizer: American Heart Association’s Scientific sessions
  • Place of Presentation: Dallas、アメリカ
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