• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Psycho-physiological mechanism of dysfunctional emotion regulation in affective disorders

Research Project

Project/Area Number 25780413
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Clinical psychology
Research InstitutionOtemon Gakuin University

Principal Investigator

Yoshimura Shinpei  追手門学院大学, 心理学部, 講師 (40646767)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords情動制御 / 認知行動療法 / 脳機能イメージング / 機械学習 / うつ病 / 脳機能画像 / 機能的結合性 / 感情障害 / 脳機能画像研究 / fMRI / 不安症 / 神経科学 / sMRI / 疼痛 / 不安障害 / 臨床心理学
Outline of Final Research Achievements

Purposes of this study was to investigate psychophysiological dysfunction in affective disorders in context of emotion regulation. I examined how anxiety or depression effects on cognitive processing of emotional stimuli and related brain functions or networks by using fMRI. As a result, I found activities of the lateral and medial prefrontal cortices in context of emotion regulation, and activation changes in these region by cognitive behavioral therapy. In addition, I suggested method which discriminate depression from healthy participant by applying the machine learning algorithm to brain activation data.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2017 2015 2014 2013

All Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 6 results,  Open Access: 5 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices.2017

    • Author(s)
      Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, Yoshino A, Ueda K, Suzuki SI, Yamawaki S.
    • Journal Title

      J Affect Disord

      Volume: 208 Pages: 610-614

    • DOI

      10.1016/j.jad.2016.10.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased amygdala reactivity following early life stress: a potential resilience enhancer role.2017

    • Author(s)
      Yamamoto T, Toki S, Siegle GJ, Takamura M, Takaishi Y, Yoshimura S, Okada G, Matsumoto T, Nakao T, Muranaka H, Kaseda Y, Murakami T, Okamoto Y, Yamawaki S
    • Journal Title

      BMC psychiatry

      Volume: 17 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s12888-017-1201-x

    • NAID

      120006814094

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Toward Probabilistic Diagnosis and Understanding of Depression Based on Functional MRI Data Analysis with Logistic Group LASSO.2015

    • Author(s)
      Shimizu Y, Yoshimoto J, Toki S, Takamura M, Yoshimura S, Okamoto Y, ... & Doya K
    • Journal Title

      PloS one

      Volume: 10 Issue: 5 Pages: 0123524-0123524

    • DOI

      10.1371/journal.pone.0123524

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support.2015

    • Author(s)
      Nishiyama Y, Okamoto Y, Kunisato Y, Okada G, Yoshimura S, Kanai Y, Yamamura T, Yoshino A, Jinnin R, Takagaki K, Onoda K, Yamawaki S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: 0127426-0127426

    • DOI

      10.1371/journal.pone.0127426

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study2015

    • Author(s)
      Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Masaru Horikoshi, Kyoko Oshita, Ryuji Nakamura, Naofumi Otsuru, Shinpei Yoshimura, Keisuke Tanaka, Koki Takagaki, Ran Jinnin, Hidehisa Yamashita, Masashi Kawamoto MD and Shigeto Yamawaki
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 69 Issue: 12 Pages: 763-772

    • DOI

      10.1111/pcn.12330

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions2015

    • Author(s)
      Tokuda T, Yoshimoto J, Shimizu Y, Toki S, Okada G, Takamura M,Yamamoto T, Yoshimura S, Okamoto Y,Yamawaki, S & Doya K.
    • Journal Title

      arXiv preprint

      Volume: 1510 Pages: 06138-06138

    • Related Report
      2015 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] 社交不安のサブタイプとビデオフィードバックによる認知機能の変化の検討2015

    • Author(s)
      村中誠司 山田紗希 吉村晋平
    • Journal Title

      不安症研究

      Volume: 印刷中

    • NAID

      130005075392

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients2014

    • Author(s)
      Hiramatsu, T., Nakanishi, K., Yoshimura, S., Yoshino, A., Adachi, N., Okamoto, Y., ... & Ochi, M
    • Journal Title

      Neuroscience Letters

      Volume: 221 Pages: 246-248

    • DOI

      10.1016/j.neulet.2014.08.027

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study.2014

    • Author(s)
      Machino, A., Kunisato, Y., Matsumoto, T., Yoshimura, S., Ueda, K., Yamawaki, Y., ... & Yamawaki, S.
    • Journal Title

      Journal of Affective Disorders

      Volume: 168 Pages: 229-235

    • DOI

      10.1016/j.jad.2014.06.030

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural Basis of Anticipatory Anxiety Reappraisals.2014

    • Author(s)
      Yoshimura, S., Okamoto, Y., Yoshino, A., Kobayakawa, M., Machino, A., & Yamawaki, S.
    • Journal Title

      PloS one

      Volume: 9 Issue: 7 Pages: e102836-e102836

    • DOI

      10.1371/journal.pone.0102836

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visual imagery while reading concrete and abstract Japanese kanji words: an fMRI study.2014

    • Author(s)
      Atsuko Hayashi, Yasumasa Okamoto, Shinpei Yoshimura, Atsuo Yoshino, Shigeru Toki, Hidehisa Yamashita, Fumio Matsuda, Shigeto Yamawaki
    • Journal Title

      Neuroscience Research

      Volume: 79 Pages: 61-66

    • DOI

      10.1016/j.neures.2013.10.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippocampal activation during associative encoding of word pairs its relation to symptomatic improvement in depression: a functional and volumetric MRI study.2014

    • Author(s)
      Shigeru Toki, Yasumasa Okamoto, Keiichi Onoda, Tomoya Matsumoto, Shinpei Yoshimura, Yoshihiko Kunisato, Go Okada, Kazuhiro Shishida, Makoto Kobayakawa, Takuji Fukumoto, Akihiko Machino, Masatoshi Inagaki, Shigeto Yamawaki
    • Journal Title

      Journal of Affective Disorders

      Volume: 152-154 Pages: 462-467

    • DOI

      10.1016/j.jad.2013.07.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking: an exploratory NIRS study.2013

    • Author(s)
      Takashi Nakao, Tomoya Matsumoto, Daisuke Shimizu, Machiko Morita, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki
    • Journal Title

      Frontiers in System Neuroscience

      Volume: 7 Pages: 1-9

    • DOI

      10.3389/fnsys.2013.00115

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study.2013

    • Author(s)
      Atsuo Yoshino, Yasumasa Okamoto, Shinpei Yoshimura, Kazuhiro Shishida, Shigeru Toki , Mitsuru Doi, Akihiko Machino, Takuji Fukumoto, Hidehisa Yamashita, Shigeto Yamawaki
    • Journal Title

      NeuroImage: Clinical

      Volume: 2 Pages: 782-789

    • DOI

      10.1016/j.nicl.2013.06.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] "認知"は人の心の問題を説明することができるか?2015

    • Author(s)
      吉村晋平
    • Organizer
      金沢大学第9回人文学類シンポジウム
    • Place of Presentation
      石川県政記念しいのき迎賓館
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] うつ病に対する認知行動療法による内側前頭前野―前帯状回間 の機能的結合性の変化について2015

    • Author(s)
      吉村晋平 岡本泰昌 松永美希 国里愛彦 小野田慶一 鈴木伸一 山脇成人
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-09-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Machine learning of fMRI data predicts treatment response to psychotherapy2013

    • Author(s)
      Yoshimura S, Shimizu Y, Okamoto Y, Toki S, Takamura M, Yoshimoto J, Doya K, Yamawaki S
    • Organizer
      日本神経科学学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 認知行動療法の脳イメージング研究の成果と今後の展望2013

    • Author(s)
      吉村晋平
    • Organizer
      第13回日本認知療法学会・日本行動療法学会第39回大会合同企画プログラム
    • Place of Presentation
      帝京平成大学
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi