Psycho-physiological mechanism of dysfunctional emotion regulation in affective disorders

• Project/Area Number: 25780413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Otemon Gakuin University
• Principal Investigator: Yoshimura Shinpei 追手門学院大学, 心理学部, 講師 (40646767)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 情動制御 / 認知行動療法 / 脳機能イメージング / 機械学習 / うつ病 / 脳機能画像 / 機能的結合性 / 感情障害 / 脳機能画像研究 / fMRI / 不安症 / 神経科学 / sMRI / 疼痛 / 不安障害 / 臨床心理学

Outline of Final Research Achievements

Purposes of this study was to investigate psychophysiological dysfunction in affective disorders in context of emotion regulation. I examined how anxiety or depression effects on cognitive processing of emotional stimuli and related brain functions or networks by using fMRI. As a result, I found activities of the lateral and medial prefrontal cortices in context of emotion regulation, and activation changes in these region by cognitive behavioral therapy. In addition, I suggested method which discriminate depression from healthy participant by applying the machine learning algorithm to brain activation data.

Research Products

• [Journal Article] Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. (2017)
  • Author(s): Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, Yoshino A, Ueda K, Suzuki SI, Yamawaki S.
  • Journal Title: J Affect Disord Volume: 208 Pages: 610-614
  • DOI: 10.1016/j.jad.2016.10.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Increased amygdala reactivity following early life stress: a potential resilience enhancer role. (2017)
  • Author(s): Yamamoto T, Toki S, Siegle GJ, Takamura M, Takaishi Y, Yoshimura S, Okada G, Matsumoto T, Nakao T, Muranaka H, Kaseda Y, Murakami T, Okamoto Y, Yamawaki S
  • Journal Title: BMC psychiatry Volume: 17 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s12888-017-1201-x
  • NAID: 120006814094
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Toward Probabilistic Diagnosis and Understanding of Depression Based on Functional MRI Data Analysis with Logistic Group LASSO. (2015)
  • Author(s): Shimizu Y, Yoshimoto J, Toki S, Takamura M, Yoshimura S, Okamoto Y, ... & Doya K
  • Journal Title: PloS one Volume: 10 Issue: 5 Pages: 0123524-0123524
  • DOI: 10.1371/journal.pone.0123524
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support. (2015)
  • Author(s): Nishiyama Y, Okamoto Y, Kunisato Y, Okada G, Yoshimura S, Kanai Y, Yamamura T, Yoshino A, Jinnin R, Takagaki K, Onoda K, Yamawaki S
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: 0127426-0127426
  • DOI: 10.1371/journal.pone.0127426
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study (2015)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Masaru Horikoshi, Kyoko Oshita, Ryuji Nakamura, Naofumi Otsuru, Shinpei Yoshimura, Keisuke Tanaka, Koki Takagaki, Ran Jinnin, Hidehisa Yamashita, Masashi Kawamoto MD and Shigeto Yamawaki
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69 Issue: 12 Pages: 763-772
  • DOI: 10.1111/pcn.12330
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions (2015)
  • Author(s): Tokuda T, Yoshimoto J, Shimizu Y, Toki S, Okada G, Takamura M,Yamamoto T, Yoshimura S, Okamoto Y,Yamawaki, S & Doya K.
  • Journal Title: arXiv preprint Volume: 1510 Pages: 06138-06138
  • Open Access / Int'l Joint Research
• [Journal Article] 社交不安のサブタイプとビデオフィードバックによる認知機能の変化の検討 (2015)
  • Author(s): 村中誠司 山田紗希 吉村晋平
  • Journal Title: 不安症研究 Volume: 印刷中
  • NAID: 130005075392
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients (2014)
  • Author(s): Hiramatsu, T., Nakanishi, K., Yoshimura, S., Yoshino, A., Adachi, N., Okamoto, Y., ... & Ochi, M
  • Journal Title: Neuroscience Letters Volume: 221 Pages: 246-248
  • DOI: 10.1016/j.neulet.2014.08.027
  • Peer Reviewed
• [Journal Article] Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. (2014)
  • Author(s): Machino, A., Kunisato, Y., Matsumoto, T., Yoshimura, S., Ueda, K., Yamawaki, Y., ... & Yamawaki, S.
  • Journal Title: Journal of Affective Disorders Volume: 168 Pages: 229-235
  • DOI: 10.1016/j.jad.2014.06.030
  • Peer Reviewed
• [Journal Article] Neural Basis of Anticipatory Anxiety Reappraisals. (2014)
  • Author(s): Yoshimura, S., Okamoto, Y., Yoshino, A., Kobayakawa, M., Machino, A., & Yamawaki, S.
  • Journal Title: PloS one Volume: 9 Issue: 7 Pages: e102836-e102836
  • DOI: 10.1371/journal.pone.0102836
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visual imagery while reading concrete and abstract Japanese kanji words: an fMRI study. (2014)
  • Author(s): Atsuko Hayashi, Yasumasa Okamoto, Shinpei Yoshimura, Atsuo Yoshino, Shigeru Toki, Hidehisa Yamashita, Fumio Matsuda, Shigeto Yamawaki
  • Journal Title: Neuroscience Research Volume: 79 Pages: 61-66
  • DOI: 10.1016/j.neures.2013.10.007
  • Peer Reviewed
• [Journal Article] Hippocampal activation during associative encoding of word pairs its relation to symptomatic improvement in depression: a functional and volumetric MRI study. (2014)
  • Author(s): Shigeru Toki, Yasumasa Okamoto, Keiichi Onoda, Tomoya Matsumoto, Shinpei Yoshimura, Yoshihiko Kunisato, Go Okada, Kazuhiro Shishida, Makoto Kobayakawa, Takuji Fukumoto, Akihiko Machino, Masatoshi Inagaki, Shigeto Yamawaki
  • Journal Title: Journal of Affective Disorders Volume: 152-154 Pages: 462-467
  • DOI: 10.1016/j.jad.2013.07.021
  • Peer Reviewed
• [Journal Article] Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking: an exploratory NIRS study． (2013)
  • Author(s): Takashi Nakao, Tomoya Matsumoto, Daisuke Shimizu, Machiko Morita, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki
  • Journal Title: Frontiers in System Neuroscience Volume: 7 Pages: 1-9
  • DOI: 10.3389/fnsys.2013.00115
  • Peer Reviewed
• [Journal Article] Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. (2013)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto, Shinpei Yoshimura, Kazuhiro Shishida, Shigeru Toki , Mitsuru Doi, Akihiko Machino, Takuji Fukumoto, Hidehisa Yamashita, Shigeto Yamawaki
  • Journal Title: NeuroImage: Clinical Volume: 2 Pages: 782-789
  • DOI: 10.1016/j.nicl.2013.06.001
  • Peer Reviewed
• [Presentation] "認知"は人の心の問題を説明することができるか？ (2015)
  • Author(s): 吉村晋平
  • Organizer: 金沢大学第9回人文学類シンポジウム
  • Place of Presentation: 石川県政記念しいのき迎賓館
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] うつ病に対する認知行動療法による内側前頭前野―前帯状回間 の機能的結合性の変化について (2015)
  • Author(s): 吉村晋平 岡本泰昌 松永美希 国里愛彦 小野田慶一 鈴木伸一 山脇成人
  • Organizer: 日本心理学会第79回大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-09-22
• [Presentation] Machine learning of fMRI data predicts treatment response to psychotherapy (2013)
  • Author(s): Yoshimura S, Shimizu Y, Okamoto Y, Toki S, Takamura M, Yoshimoto J, Doya K, Yamawaki S
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都国際会議場
• [Presentation] 認知行動療法の脳イメージング研究の成果と今後の展望 (2013)
  • Author(s): 吉村晋平
  • Organizer: 第13回日本認知療法学会・日本行動療法学会第39回大会合同企画プログラム
  • Place of Presentation: 帝京平成大学
  • Invited