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Microwave-assisted Rapid Fabrication of Monolithic Stationary Phases for Capillary Liquid Chromatography

Research Project

Project/Area Number 25810085
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Analytical chemistry
Research InstitutionGifu University

Principal Investigator

Lim Lee Wah  岐阜大学, 工学部, 准教授 (80377689)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsキャピラリーモノリス固定相 / 迅速・簡便調製法 / マイクロ波 / ポロゲンレス調製法 / マレイン酸系モノリスカラム / ポロゲンレス / 有機ポリマー系モノリス / キャピラリーカラム / キャピラリーLC / モノリスカラム / 迅速調製法
Outline of Final Research Achievements

Monolithic columns, which consist of μm-sized skeletons and through-pores, could offer high separation efficiency with ultra low flow resistance, and they have attracted much attention since their introduction in the early 1990s. In this research, rapid fabrication of monolithic silica- and polymer-based capillary columns was evaluated using microwave irradiation. The reaction solution was filled into fused-silica capillary tubing and the column was then irradiated at different time under various temperature and output control of the microwave device. The morphology of the monoliths was observed with a scanning electron microscope and was compared to those monoliths that were fabricated under normal thermal conditions. The results showed that the degree of output of the microwave device had direct influence on the morphology as well as size of the skeleton backbone of the monoliths.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2015 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results)

  • [Journal Article] Polymer monolithic methacrylate base modified with tosylated-polyethylene glycol monomethyl ether as stationary phase for capillary liquid chromatography2015

    • Author(s)
      A. Rahayu, L. W. Lim, T. Takeuchi
    • Journal Title

      Talanta

      Volume: 134 Pages: 232-238

    • DOI

      10.1016/j.talanta.2014.10.060

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of column hardware on liquid chromatography-mass spectrometry of phosphorylated compounds2015

    • Author(s)
      H. Sakamaki, T. Uchida, L. W. Lim, T. Takeuchi
    • Journal Title

      J. Chromatogr. A

      Volume: 1381 Pages: 125-131

    • DOI

      10.1016/j.chroma.2014.12.088

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Column Carryover of Phosphorylated Peptides and Fumonisins by Duplicated Solvent Gradient Method in Liquid Chromatography/Tandem Mass Spectrometry2015

    • Author(s)
      H. Sakamaki, T. Uchida, L. W. Lim, T. Takeuchi
    • Journal Title

      Analytical Sciences

      Volume: 31 Issue: 2 Pages: 91-97

    • DOI

      10.2116/analsci.31.91

    • NAID

      130004827459

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of hybrid monolithic stationary phase with allylsulfonate for the rapid and simultaneous separation of cations in capillary ion chromatography2015

    • Author(s)
      A. Rahayu, L. W. Lim, T. Takeuchi
    • Journal Title

      J. Sep. Sci.

      Volume: 38 Issue: 7 Pages: 1109-1116

    • DOI

      10.1002/jssc.201401264

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcuminoid’s Content and Fingerprint Analysis for Authentication and Discrimination of Curcuma xanthorrhiza from Curcuma longa by High-Performance Liquid Chromatography-Diode Array Detector2015

    • Author(s)
      M. Rafi, L. Wulansari, R. Heryanto, L. K. Darusman, L. W. Lim, T. Takeuchi
    • Journal Title

      Food Anal. Methods

      Volume: 8 Issue: 9 Pages: 2185-2193

    • DOI

      10.1007/s12161-015-0110-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Micro-Flow-Controlled Techniques and Novel Stationary Phases in Capillary Liquid Chromatography2015

    • Author(s)
      L. W. Lim
    • Journal Title

      CHROMATOGRAPHY

      Volume: 36 Issue: 1 Pages: 1-12

    • DOI

      10.15583/jpchrom.2015.011

    • NAID

      130005069046

    • ISSN
      1342-8284, 1348-3315
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Chemically Bonded Crown Ether Stationary Phases in Capillary Ion Chromatography2014

    • Author(s)
      L. W. Lim, K. Tokunaga, T. Takeuchi
    • Journal Title

      CHROMATOGRAPHY

      Volume: 35 Issue: 2 Pages: 95-101

    • DOI

      10.15583/jpchrom.2014.012

    • NAID

      130005057719

    • ISSN
      1342-8284, 1348-3315
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation and Characterization of Long Alkyl Chain Methacrylate-Based Monolithic Column for Capillary Chromatography in Separation of Alkylbenzene Compound2014

    • Author(s)
      Hilma, A. Rahmah, F. Mairizki, R. Putri, R. Zein, E. Munaf, T. Takeuchi and L. W. Lim
    • Journal Title

      Asian J. Chem.

      Volume: 26 Pages: 3595-3599

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eluent‑Induced Separation of Inorganic Cations in Capillary Liquid Chromatography with Contactless Conductivity Detector2014

    • Author(s)
      F. Earnestly, L. W. Lim, T. Takeuchi
    • Journal Title

      Chromatographia

      Volume: 77 Pages: 1539-1544

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Poly(ethylene oxide)-bonded stationary phase for separation of inorganic anions in capillary ion chromatography2013

    • Author(s)
      R. Linda, L. W. Lim, T. Takeuchi
    • Journal Title

      J. Chromatogr. A

      Volume: 1294 Pages: 117-121

    • DOI

      10.1016/j.chroma.2013.04.052

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Methacrylate-based Diol Monolithic Stationary Phase for the Separation of Polar and Non-Polar Compounds in Capillary Liquid Chromatography2013

    • Author(s)
      R. Linda, L. W. Lim, T. Takeuchi
    • Journal Title

      Analytical Sciences

      Volume: 29 Issue: 6 Pages: 631-635

    • DOI

      10.2116/analsci.29.631

    • NAID

      10031177786

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Study on Zirconium Introduction to Silica Monolithic Capillary Column2015

    • Author(s)
      Y. Horibe, L. W. Lim, T. Takeuchi
    • Organizer
      4th International Conference on Chemical Sciences (4th ICCS)
    • Place of Presentation
      Padang, Indonesia
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microwave-assisted Fabrication of Stationary Phases for Capillary Liquid Chromatography2015

    • Author(s)
      L. W. Lim
    • Organizer
      4th International Conference on Chemical Sciences (4th ICCS)
    • Place of Presentation
      Padang, Indonesia
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microwave-assisted Rapid Fabrication of Monolithic Stationary Phases for Capillary Liquid Chromatography2015

    • Author(s)
      L. W. Lim, T. Takeuchi
    • Organizer
      The Second ASIAN SYMPOSIUM ON ANALYTICAL SCIENCES (2nd ASAS)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Dendritic Polymer-based Stationary Phases for Capillary Liquid Chromatography2015

    • Author(s)
      I. Kawase, L. W. Lim, T. Takeuchi
    • Organizer
      The 8th Asia-Pacific Symposium on Ion Analysis
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microwave-assisted Rapid Fabrication of Polymeric Sulfobetaine Stationary Phases for Capillary Ion Chromatography2015

    • Author(s)
      L. W. Lim, Y. Ito, T. Takeuchi
    • Organizer
      The 8th Asia-Pacific Symposium on Ion Analysis
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Sulfonate Monolithic Columns for Rapid and Simultaneous Separation of Inorganic Cations in Capillary Ion Chromatography2015

    • Author(s)
      A. Rahayu, L. W. Lim, T. Takeuchi
    • Organizer
      The 8th Asia-Pacific Symposium on Ion Analysis
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Immobilized Enzymatic Trypsin Micro-reactor on Polymer Monolith Column for Biocatalytic Reactions by Using Capillary Chromatography2015

    • Author(s)
      R. Putri, L. W. Lim, T. Takeuchi
    • Organizer
      The 8th Asia-Pacific Symposium on Ion Analysis
    • Place of Presentation
      Makuhari Messe, Chiba
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Poly(ethyleneglycol) Methylether Methacrylate-bonded Stationary Phase in Capillary Ion Chromatography2015

    • Author(s)
      L. Rong, L. W. Lim, T. Takeuchi
    • Organizer
      第22回クロマトグラフィーシンポジウム
    • Place of Presentation
      近畿大学, 東大阪
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tosylated-polyethylene glycol monomethyl ether-bonded polymeric monolith as a stationary phase for capillary liquid chromatography2013

    • Author(s)
      Aster Rahayu, Lee Wah Lim, Toyohide Takeuchi
    • Organizer
      日本分析化学会有機微量分析研究懇談会創立60周年記念大会シンポジウム
    • Place of Presentation
      長良川国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Application of capillary liquid chromatography for the routine analysis of inorganic ions in commercially refillable drinking water in Indonesia2013

    • Author(s)
      Refilda Suhaili, Aster Rahayu, Lee Wah Lim, Toyohide Takeuchi
    • Organizer
      日本分析化学会有機微量分析研究懇談会創立60周年記念大会シンポジウム
    • Place of Presentation
      長良川国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of highly functionalized zwitterionic monolithic columns for capillary liquid chromatography2013

    • Author(s)
      Lee Wah Lim, Toyohide Takeuchi
    • Organizer
      44th World Chemistry Congress
    • Place of Presentation
      Harbiye Military Museum and Convention Center & Lütfi Kırdar Congress and Exhibition Center, Istanbul, Turkey
    • Related Report
      2013 Research-status Report
  • [Presentation] Zwitterionic Monolithic Columns for Capillary Ion Chromatography2013

    • Author(s)
      Lee Wah Lim, Toyohide Takeuchi
    • Organizer
      2013 China-Japan-Korea Symposium on Analytical Chemistry
    • Place of Presentation
      Fukuoka and Nagasaki, Japan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] マイクロ波支援によるポリマー系モノリス固定相の迅速調製に関する研究2013

    • Author(s)
      伊藤 優貴,リム リーワ,竹内 豊英
    • Organizer
      第32回分析化学中部夏期セミナープログラム
    • Place of Presentation
      休暇村能登千里浜コンベンションホール
    • Related Report
      2013 Research-status Report
  • [Presentation] Separation science and technology – fundamentals and applications2013

    • Author(s)
      Lee Wah Lim
    • Organizer
      2nd International Young Scientist Conference on Analytical Sciences (IYSCAS II)
    • Place of Presentation
      Convention Hall of Andalas University, Padang, Indonesia
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Amino-functionalized Stationary Phases for Capillary Ion Chromatography2013

    • Author(s)
      Lee Wah Lim, Yoshiki Kojima, Takahito Abe, Toyohide Takeuchi
    • Organizer
      7th Asia Pacific Symposium on Ion Analysis
    • Place of Presentation
      Lotte Hotel Jeju, Jeju Island, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] キャピラリーイオンクロマトグラフィーにおける PEG有機ポリマーモノリス固定相の開発2013

    • Author(s)
      安立 駿也,リム リーワ,竹内 豊英
    • Organizer
      第30回イオンクロマトグラフィー討論会
    • Place of Presentation
      (株)豊田中央研究所 厚生センター アクタス
    • Related Report
      2013 Research-status Report
  • [Presentation] キャピラリーイオンクロマトグラフィーにおけるアミノ酸結合型ポリマーモノリス固定相の開発2013

    • Author(s)
      森 文香,リム リーワ,竹内 豊英
    • Organizer
      第30回イオンクロマトグラフィー討論会
    • Place of Presentation
      (株)豊田中央研究所 厚生センター アクタス
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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