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Structural and functional analysis of the huge compound produced by the dinoflagellate

Research Project

Project/Area Number 25810096
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bio-related chemistry
Research InstitutionGifu University

Principal Investigator

INUZUKA Toshiyasu  岐阜大学, 生命科学総合研究支援センター, 助教 (50467271)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords渦鞭毛藻 / 巨大分子 / ポリオール / NMR / 質量分析 / 構造解析 / 分解反応 / MS/MS
Outline of Final Research Achievements

A huge molecule, SCC5148, produced by the dinoflagellate Amphidinium sp. was isolated and analyzed its partial structure. Some partial structures of SCC5148 were revealed by the 2D-NMR spectra. Degradation reaction of SCC5148 gave many segments, and one of them was determined its structure. Additionally, novel huge molecules, amdigenols E and G, produced by the same dinoflagellate were isolated and determined their structures with 2D-NMR spectra and MS/MS analyses. Amdigenols have the common partial structures, and the some NMR signals of amdigenols were similar to those of SCC5148. This extrapolates that SCC5148 have the partial structures of amdigenols.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Amdigenols E and G, long carbon-chain polyol compounds, isolated from the marine dinoflagellate Amphidinium sp.2014

    • Author(s)
      Toshiyasu Inuzuka, Kaoru Yamada, Daisuke Uemura
    • Journal Title

      Tetrahedron Letters

      Volume: 55 Issue: 46 Pages: 6319-6323

    • DOI

      10.1016/j.tetlet.2014.09.094

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 渦鞭毛藻由来超炭素鎖化合物の探索2015

    • Author(s)
      犬塚俊康
    • Organizer
      第四回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
    • Place of Presentation
      岐阜薬科大学
    • Year and Date
      2015-03-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Long Carbon-Chain Polyols Isolated from the Marine Dinoflagellate Amphidinium sp.2014

    • Author(s)
      Toshiyasu Inuzuka
    • Organizer
      1st Joint International Seminar of Faculty of Science and Technology (University Kebangsaan Malaysia) and Faculty of Engineering (Gifu University) 2014
    • Place of Presentation
      岐阜大学
    • Year and Date
      2014-07-31 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 渦鞭毛藻Amphidinol sp.由来の様々な炭素鎖長から成るポリオール化合物群の構造解析2014

    • Author(s)
      犬塚俊康,山田薫,上村大輔
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 渦鞭毛藻Amphidinium sp.の産生するポリオール化合物群の構造解析2013

    • Author(s)
      犬塚俊康,山田薫,上村大輔
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      同志社大学寒梅館,京都
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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