Functional analysis of the reactivation of neuronal activity in the olfactory cortex sharp waves

• Project/Area Number: 25830003
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: The University of Tokyo
• Principal Investigator: MANABE Hiroyuki 東京大学, 医学(系)研究科(研究院), 助教 (80511386)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 嗅覚 / 電気生理 / 睡眠 / 梨状皮質 / 前頭眼窩皮質 / 嗅結節 / Tenia Tecta / 摂食モチベーション / 鋭波 / 嗅皮質 / 徐波 / 再活性化 / 神経科学

Outline of Final Research Achievements

(1)We simultaneously recorded local field potential and spike activities in the anterior piriform cortex (APC) and orbitofrontal cortex (OFC) during slow-wave sleep. We found a clear temporal coordination of the up-down states between APC and OFC. The sharp waves in the APC tended to occur just after the transition from the down state to up state and just before the transition from the up state and down state in the OFC. These results suggest that the up-down state in the OFC provides a common temporal framework for the interactions between the APC and OFC during slow-wave sleep.
(2)We found the eating neurons that changed in the firing frequency during the odor induced food-seeking and feeding behavior in the olfactory tubercle and the Tenia Tecta. These results suggest that the olfactory tubercle and Tenia Tecta play crucial roles in the odor-induced motivated behaviors.

Research Products

• [Journal Article] Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb (2014)
  • Author(s): Komano-Inoue S., Manabe H. Ota, M. Kusumoto-Yoshida I., Yokoyama T, Mori, K. and Yamaguchi M.
  • Journal Title: Eur. J. Neurosci. Volume: 40 Issue: 5 Pages: 2724-2733
  • DOI: 10.1111/ejn.12679
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex and orbitofrontal cortex. (2013)
  • Author(s): Mori K, Manabe H, Narikiyo K, Onisawa N
  • Journal Title: Frontiers in Psychology Volume: 4 Pages: 743-743
  • DOI: 10.3389/fpsyg.2013.00743
  • Peer Reviewed
• [Journal Article] Reorganization of neuronal circuits of the central olfactory system during postprandial sleep (2013)
  • Author(s): Yamaguchi M, Manabe H, Murata K, and Mori K
  • Journal Title: Frontiers in neural Circuits Volume: 7 Pages: 132-132
  • DOI: 10.3389/fncir.2013.00132
  • Peer Reviewed
• [Presentation] Behavioral state-dependent change in respiration pattern and information processing modes of the olfactory systems in freely behaving rats (2013)
  • Author(s): 眞部寛之、森憲作
  • Organizer: 日本神経科学大会 Neuro2013
  • Place of Presentation: 京都国際会館 京都府
• [Presentation] Coordinated activity of anterior piriform cortex and orbitofrontal cortex during slow-wave sleep (2013)
  • Author(s): 鬼沢菜穂美、眞部寛之、森憲作
  • Organizer: 日本神経科学大会 Neuro2013
  • Place of Presentation: 京都国際会館 京都府
• [Presentation] The respiration rhythm-paced fast and slow-gamma oscillation in the olfactory bulb (2013)
  • Author(s): 眞部寛之、森憲作
  • Organizer: 第11回国際シンポジウム「味覚嗅覚の分子神経機構」
  • Place of Presentation: 九州大学馬出キャンパス 福岡県