| Project/Area Number |
25830008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アクティブゾーン / シナプス / 神経回路 / 脳機能 / 条件付き遺伝子欠損 / Cre-loxP / Cre-loxPシステム / アクティブゾーン構成蛋白質 / 脳領域特異的ELKS欠損マウス / シナプス微細構造 |
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| Outline of Final Research Achievements |
To understand neural network, it is indispensable to understand the process of synaptic transmission. In this project, I focused on the presynaptic terminal protein called CAST/ELKS, and analyzed brain function of deletion mutants through their synaptic neurotransmission. (1) The deletion mutant of ELKS had little phenotype, probably because its function was complementary supported by CAST. (2) The CAST/ELKS deletion mutants showed various phenotypes depending on the each deficient region of the brain. The results of this project suggested that CAST/ELKS have various mechanisms relating to their located synapse and neural network.
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