Evaluation of usability of IL1RAPL1 knockout mice as an animal model of neuropsychiatric disorders
| Project/Area Number |
25830048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 行動解析 / シナプスオーガナイザー / 知的障害 / 自閉症 / IL1RAPL1 / シナプス形成 / 行動テストバッテリー |
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| Outline of Final Research Achievements |
The spine density of basal dendrites of cortical layer 2/3 and hippocampal CA1 pyramidal neurons was significantly reduced in IL1RAPL1 knockout mice. We found that the spatial reference and working memories and remote fear memory were impaired in IL1RAPL1 knockout mice. These results suggest that IL1RAPL1 knockout mice are an animal model of intellectual disability. IL1RAPL1 knockout mice also exhibited slightly reduced behavioural flexibility and increased sociability. In addition, IL1RAPL1 knockout mice exhibited high locomotor activity and reduced open-space and height anxiety-like behaviours.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours.2014
Author(s)
Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
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Journal Title
Scientific Reports
Volume: 4: 6613
Issue: 1
Pages: 6613-6613
DOI
Related Report
Peer Reviewed / Open Access
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