Expression and function of Siglec-H in the nervous system
| Project/Area Number |
25830050
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
Konishi Hiroyuki 名古屋大学, 医学(系)研究科(研究院), 助教 (90448746)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | ミクログリア / マクロファージ / マーカー / 炎症 / グリア / 神経損傷 / 神経再生 / 抗体 / モノクローナル抗体 |
|---|
| Outline of Final Research Achievements |
We examined the possibility that sialic acid binding Ig-like lectin (Siglec)-H was a novel microglial marker. We revealed that Siglec-H was expressed in microglia but not macrophages and furthermore that Siglec-H locus is useful for microglia-specific gene targeting using Siglec-H knock-in mouse. We also performed functional analysis of Siglec-H-deficient mouse and found that Siglec-H might suppress inflammatory responses of microglia after neuronal injury.
|
Report
(4 results)
Research Products
(17 results)
