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Analysis of the molecular mechanism for primordial follicle activation

Research Project

Project/Area Number 25830061
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUZUKI Hitomi  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60644094)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords原始卵胞 / 卵巣機能 / 卵胞成熟 / マウス / 転写因子
Outline of Final Research Achievements

Folliculogenesis in mammals is a complex process involving bi-directional communication between the oocyte and surrounding soma. In the mouse ovary, primordial follicles (PrdFs) that contain 15um oocyte surrounded by flatten soma are formed shortly after birth, and provide a source of future growing follicles during the entire reproductive lifespan. PrdFs remain dormant for prolonged intervals. For retaining a long female reproductivity, it is essential to manage both ‘dormancy’ and ‘activation’ of PrdF and to prevent the consumption of all PrdF in a short period. In this study, we revealed the part of function of Sohlh1 and Sohlhl2, which are the oocyte- specific transcription factors.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads.2014

    • Author(s)
      Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y.
    • Journal Title

      Reproduction

      Volume: 148 Issue: 6 Pages: H1-H9

    • DOI

      10.1530/rep-14-0171

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spermatogonial SOHLH1 nucleocytoplasmic shuttling associates with initiation of spermatogenesis in the rhesus monkey (Macaca mulatta)2014

    • Author(s)
      Ramaswamy S, Razack BS, Roslund RM, Suzuki H, Marshall GR, Rajkovic A, *Plant TM.
    • Journal Title

      Mol Hum Reprod

      Volume: 20 Issue: 4 Pages: 360-357

    • DOI

      10.1093/molehr/gat093

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Transition From Stem Cell to Progenitor Spermatogonia and Male Fertility Requires the SHP2 Tyrosine Phosphatase.2014

    • Author(s)
      Puri P., Phillips B.T., Suzuki H., Orwig K.E., Rajkovic A., Lapinski P.E., King P.D., Feng G.S., *Walker W.
    • Journal Title

      Stem Cells

      Volume: 32 Issue: 3 Pages: 741-753

    • DOI

      10.1002/stem.1572

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 転写因子Sohlh1を起点とする卵胞成熟分子機構の解析2014

    • Author(s)
      鈴木仁美, Aleksandar Rajkovic, 金井正美
    • Organizer
      第61回実験動物学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胚の子宮着床における転写因子Sox17の機能解析2014

    • Author(s)
      川澄みゆり、鈴木仁美、金井克晃、金井正美
    • Organizer
      第61回実験動物学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス卵巣における原始卵胞の休眠維持と活性化の制御機構2013

    • Author(s)
      鈴木仁美、金井正美
    • Organizer
      第60回実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Hsp-Sry Tgマウスを用いた精巣決定遺伝子SRYの標的遺伝子の同定2013

    • Author(s)
      Kento Miura, Kyoko Harikae, Mai Shinomura, Mayu Nakaguti, Ayako Tomita, Naoki Tsunekawa, Hitomi Suzuki, Masami Kanai, Masamichi Kuroumaru, Yoshiakira Kanai.
    • Organizer
      第106回 日本繁殖生物学会大会
    • Place of Presentation
      東京農工大学農学部府中キャンパス
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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