Analysis of the molecular mechanism for primordial follicle activation
Project/Area Number |
25830061
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Laboratory animal science
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
SUZUKI Hitomi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60644094)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 原始卵胞 / 卵巣機能 / 卵胞成熟 / マウス / 転写因子 |
Outline of Final Research Achievements |
Folliculogenesis in mammals is a complex process involving bi-directional communication between the oocyte and surrounding soma. In the mouse ovary, primordial follicles (PrdFs) that contain 15um oocyte surrounded by flatten soma are formed shortly after birth, and provide a source of future growing follicles during the entire reproductive lifespan. PrdFs remain dormant for prolonged intervals. For retaining a long female reproductivity, it is essential to manage both ‘dormancy’ and ‘activation’ of PrdF and to prevent the consumption of all PrdF in a short period. In this study, we revealed the part of function of Sohlh1 and Sohlhl2, which are the oocyte- specific transcription factors.
|
Report
(3 results)
Research Products
(7 results)
-
[Journal Article] A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads.2014
Author(s)
Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y.
-
Journal Title
Reproduction
Volume: 148
Issue: 6
Pages: H1-H9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
[Presentation] Hsp-Sry Tgマウスを用いた精巣決定遺伝子SRYの標的遺伝子の同定2013
Author(s)
Kento Miura, Kyoko Harikae, Mai Shinomura, Mayu Nakaguti, Ayako Tomita, Naoki Tsunekawa, Hitomi Suzuki, Masami Kanai, Masamichi Kuroumaru, Yoshiakira Kanai.
Organizer
第106回 日本繁殖生物学会大会
Place of Presentation
東京農工大学農学部府中キャンパス
Related Report