|Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|Outline of Final Research Achievements
Islet transplantation has been suggested to be a promising treatment for type 1 and type 2 diabetes. iPS cells have potential cure for diabetes using a cellular therapy to ameliorate symptoms associated with both reduced insulin secretion and insulin sensitivity. Therefore, highly efficient differentiation of iPS cells into insulin-secreting cells will enhance the potential for patient specific cell transplantation therapy in diabetes. Here, we demonstrate that mouse-derived iPS cells can be differentiated into insulin-secreting cells in vitro and that they respond to glucose stimulation under physiological conditions. The hyperglycemic phenotype in model mice was improved by transplantation of the insulin-secreting cells.