Pigment epithelium-derived factor as a target for development of new animal model of arteriosclerosis

• Project/Area Number: 25830067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Kurume University
• Principal Investigator: Matsui Takanori 久留米大学, 医学部, 講師 (10425233)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 血管保護作用 / 動脈硬化症 / モデル動物 / PEDF受容体 / 動脈硬化症治療法

Outline of Final Research Achievements

We identified laminin receptor as a functional receptor for pigment epithelium-derived factor (PEDF) which act atheroprotective. We investigated PEDF exert atheroprotective effects via association with laminin receptor. To investigate how arteriosclerosis develop, we generated laminin receptor transgenic (LR-Tg) mice that ubiquitously express human laminin receptor.