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The Relationship of Myeloma cells, Stromal cells and Monocyte under bone marrow microenvironment

Research Project

Project/Area Number 25830120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionSapporo Medical University

Principal Investigator

IKEDA HIROSHI  札幌医科大学, 道民医療推進学講座, 助教 (60570132)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多発性骨髄腫 / 単球 / 骨髄腫 / 骨髄微小環境
Outline of Final Research Achievements

Multiple myeloma (MM) is a disease characterized by clonal B-cell tumors of slowly proliferating plasma cells within the bone marrow. yeloma cells contacts with bone marrow stromal cells (BMSCs), which secrete factors/cytokines, Our results therefore suggest that the role of monocyte is an important component of the BM microenvironment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.2015

    • Author(s)
      池田 博
    • Journal Title

      Onco Targets Ther.

      Volume: Oct 5;8: Pages: 2805-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.2015

    • Author(s)
      石黒 一也、池田 博
    • Journal Title

      Int J Hematol.

      Volume: Aug;102(2):200-4 Pages: 200-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Interaction between monocytes and bone marrow microenvironment in pathogenesis of multiple myeloma2014

    • Author(s)
      池田 博
    • Organizer
      日本がん学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] THE RELATIONSHIP OF MYELOMA CELLS, STROMAL CELLS AND MONOCYTES UNDER BONE MARROW MICROENVIRONMENT2013

    • Author(s)
      Ikeda Hiroshi
    • Organizer
      ヨーロッパ血液学会
    • Place of Presentation
      ストックホルム、スウエーデン
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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