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Regulation of chromatin structure and gene expression in cross-tolerance to environmental stress

Research Project

Project/Area Number 25840007
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Research InstitutionKyoto University

Principal Investigator

TARUMOTO Yusuke  京都大学, 生命科学研究科, 助教 (70551381)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsストレス応答 / シグナル伝達 / 遺伝子発現制御 / クロマチン / 分子生物学
Outline of Final Research Achievements

We have studied cellular responses to low-dose environmental stress. Cross-tolerance is an adaptive phenomenon, in which exposure to low-dose stress confers transient resistance to other form of high-dose stress. Previously we have identified Cpc2 as an important factor for cross-tolerance. This study revealed that Cpc2 plays a role in the regulation of stress-induced gene expression via facilitating nucleosome remodeling.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Cellular response to low-dose stress2014

    • Author(s)
      樽本雄介、石川冬木
    • Journal Title

      Leading Author's

      Volume: 3 Pages: e004

    • DOI

      10.7875/leading.author.3.e004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast2013

    • Author(s)
      Tarumoto, Y. Kanoh, J. Ishikawa, F.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288(26) Issue: 26 Pages: 19260-19268

    • DOI

      10.1074/jbc.m112.445270

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 分裂酵母Stn1の染色体構造維持における役割2014

    • Author(s)
      滝川 雅大、樽本 雄介、石川 冬木
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fission yeast HIRA histone chaperone facilitates stress-induced transcriptional response2014

    • Author(s)
      Yusuke Tarumoto, Moeko Chujo, Koichi Miyatake, Eisuke Nishida, and Fuyuki Ishikawa
    • Organizer
      IIAS Research Conference 2014: Chromatin Decoding
    • Place of Presentation
      京都
    • Year and Date
      2014-05-12 – 2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fission yeast Cpc2 facilitates stress-activated MAP kinase-mediated stress response2013

    • Author(s)
      Yusuke Tarumoto, Junko Kanoh, Toshihide Ueno, Hiroyuki Mano, Fuyuki Ishikawa
    • Organizer
      EMBO Conference on Fission Yeast: pombe 2013
    • Place of Presentation
      イギリス、ロンドン
    • Related Report
      2013 Research-status Report
  • [Presentation] 分裂酵母Cpc2はストレス応答性MAPキナーゼを介したストレス応答を促進する2013

    • Author(s)
      樽本雄介、加納純子、上野敏秀、間野博行、石川冬木
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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