Bioinspired synthesis and structural elucidation of natural naphthoquinone dimers
| Project/Area Number |
25850083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
KURAMOCHI Kouji 京都府立大学, 生命環境科学研究科(系), 准教授 (90408708)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 天然物合成 / 生合成模倣 / 1,4-ナフトキノン / 二量化 / 絶対立体配置 / 全合成 / 天然物 / ナフトキノン |
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| Outline of Final Research Achievements |
Juglorubin, which was isolated from Streptomyces sp., is a red ionic dye. It has been proposed that the biosynthetic pathway to juglorubin might include dimerization of juglomycin C and formation of juglocombin A as a key biosynthetic intermediate. The relative configuration of juglorubin has been determined by X-ray crystallography. However, the absolute configuration of this compound as well as juglocombin A still remains unknown. The aims of this research are 1) total synthesis of natural 1,4-naphthoquinone dimers based on the plausible biogenetic pathway, 2) determination of the absolute configuration of these compounds.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Dimerization Reactions of 2-Bromo-3,5,6-trimethyl-1,4-benzoquinone2013
Author(s)
Shuhei Azuma, Motohiro Ota, Akito Ishida, Katsuhiro Isozaki, Hikaru Takaya, Masaharu Nakamura, Takahiro Sasamori, Norihiro Tokitoh, Kouji Kuramochi, Kazunori Tsubaki
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Journal Title
Chemistry Letters
Volume: 42
Issue: 12
Pages: 1531-1533
DOI
NAID
Related Report
Peer Reviewed
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