Research Project
Grant-in-Aid for Young Scientists (B)
Field isolates of Marek’s disease virus (MDV) have tended to increase in virulence, and therefore, the development of more effective vaccines would be desirable. To develop a novel vaccine, we focused on the PD1/PD-L1 pathway that contributes to the immune suppression, and reconstituted the recombinant MDVs that carry the soluble-PD1 gene to competitively inhibit the immunosuppression regulated by the endogenous PD1. The recombinant vaccine expressing soluble PD1 induced higher production of interferon γ in the immune cells from the vaccinated chickens, indicating that this vaccine potentially possesses an ability to induce more effective cell-mediated immunity in chickens.
All 2015 2014 2013
All Journal Article (23 results) (of which Peer Reviewed: 20 results, Open Access: 3 results, Acknowledgement Compliant: 2 results) Presentation (30 results) Book (1 results)
J Vet Med Sci.
Volume: In press
130005094682
Insect Biochem Mol Biol.
Volume: in press Pages: 59-67
10.1016/j.ibmb.2015.01.010
Veterinary immunology and immunopathology
Volume: 163 Issue: 3-4 Pages: 115-124
10.1016/j.vetimm.2014.10.006
PLoS One
Volume: 9 Issue: 6 Pages: e98415-e98415
10.1371/journal.pone.0098415
Microbiol Immunol
Volume: 58 Issue: 7 Pages: 388-397
10.1111/1348-0421.12160
J Gen Virol
Volume: 95 Issue: 8 Pages: 1832-1842
10.1099/vir.0.065011-0
Vet. Parasitol.
Volume: in press Issue: 3-4 Pages: 180-93
10.1016/j.vetpar.2014.02.056
酪農ジャーナル
Volume: 67 Pages: 29-31
Arch. Virol.
Immunology
Volume: (印刷中) Issue: 4 Pages: 551-61
10.1111/imm.12243
Insect Mol. Biol.
Volume: in press Issue: 4 Pages: 466-74
10.1111/imb.12101
Infect Genet Evol.
Volume: 16C Pages: 137-143
10.1016/j.meegid.2012.12.032
120005317003
Vet Rec.
Volume: 173 Issue: 21 Pages: 527-527
10.1136/vr.101833
Microbiology and Immunology.
Volume: 58 Issue: 8 Pages: 600-604
10.1111/1348-0421.12073
Veterinary Research
Volume: 44 Issue: 1 Pages: 59-59
10.1186/1297-9716-44-59
Parasitol Int.
Volume: 62 Issue: 5 Pages: 448-453
10.1016/j.parint.2013.06.002
Vet Immunol Immunopathol.
Volume: in press Issue: 1-2 Pages: 153-158
10.1016/j.vetimm.2013.02.002
Comp Immunol Microbiol Infect Dis.
Volume: 36 Issue: 1 Pages: 63-9
10.1016/j.cimid.2012.09.005
Ticks Tick Borne Dis.
Volume: 4 Issue: 1-2 Pages: 138-44
10.1016/j.ttbdis.2012.11.001
J. Vet. Med Sci.
Volume: 75 Pages: 538-540
130001879630
動物用ワクチンーバイオ医薬品研究会ニュースレター
Volume: 7 Pages: 19-20
DAIRYMAN
Volume: 30 Pages: 60-62
Parasitol Res.
Volume: 112 Issue: 4 Pages: 1513-1521
10.1007/s00436-013-3297-3