| Project/Area Number |
25850222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Tokyo University of Agriculture (2014)
Jichi Medical University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 妊娠 / 妊娠高血圧症候群 / 自然炎症 / インフラマソーム |
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| Outline of Final Research Achievements |
Preeclampsia is a pregnancy-specific syndrome characterized by elevated blood pressure, proteinuria, and intrauterine growth restriction (IUGR). Although sterile inflammation appears to be involved, its pathogenesis remains unclear. Here we investigated the role of the NLRP3 inflammasomes in the pathogenesis of preeclampsia using Nlrp3-deficient pregnant mice. During pregnancy in mice, continuous infusion of angiotensin II (AII) induced hypertension, proteinuria, and IUGR. AII-induced hypertension was prevented in Nlrp3 deficient mice. Although NLRP3 deficiency had no effect on IUGR, it restored IL-6 upregulation in the placenta and kidney of AII-infused mice. These findings demonstrate that NLRP3 contributes to the development of gestational hypertension independently of the inflammasomes.
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