Mechanism of pregnancy induced hypertension via inflammatory response
Project/Area Number |
25850222
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Integrative animal science
|
Research Institution | Tokyo University of Agriculture (2014) Jichi Medical University (2013) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 妊娠 / 妊娠高血圧症候群 / 自然炎症 / インフラマソーム |
Outline of Final Research Achievements |
Preeclampsia is a pregnancy-specific syndrome characterized by elevated blood pressure, proteinuria, and intrauterine growth restriction (IUGR). Although sterile inflammation appears to be involved, its pathogenesis remains unclear. Here we investigated the role of the NLRP3 inflammasomes in the pathogenesis of preeclampsia using Nlrp3-deficient pregnant mice. During pregnancy in mice, continuous infusion of angiotensin II (AII) induced hypertension, proteinuria, and IUGR. AII-induced hypertension was prevented in Nlrp3 deficient mice. Although NLRP3 deficiency had no effect on IUGR, it restored IL-6 upregulation in the placenta and kidney of AII-infused mice. These findings demonstrate that NLRP3 contributes to the development of gestational hypertension independently of the inflammasomes.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.2014
Author(s)
Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
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Journal Title
Nanotoxicology
Volume: 11
Issue: 5
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages2014
Author(s)
Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
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Journal Title
PLoS One
Volume: 9
Issue: 12
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes.2014
Author(s)
Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki, Nishimura S, Sagara J, Noda T, IwakuraY, Hiroko Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
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Journal Title
J Immunol
Volume: 192(9)
Issue: 9
Pages: 4342-4351
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ASC in Renal Collecting Duct Epithelial Cells Contributes to Inflammation and Injury after Unilateral Ureteral Obstruction2014
Author(s)
Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
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Journal Title
American Journal of Pathology
Volume: 184(5)
Issue: 5
Pages: 1287-1298
DOI
Related Report
Peer Reviewed / Open Access