| Project/Area Number |
25860001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
SASANO Yusuke 東北大学, 薬学研究科(研究院), 助教 (10636400)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アルコール酸化反応 / 酸化的速度論的光学分割 / アミノアルコール / ニトロキシルラジカル / 銅 / キラルオキサゾリン |
|---|
| Outline of Final Research Achievements |
Highly chemoslective aerobic alcohol oxidation using nitroxyl radical-copper catalysis has been developed. During close optimization of the reaction conditions by using various alcohols, we found that the optimum combination of nitroxyl radical, copper salt, and solution concentration was dependent on the type of substrate. Various alcohols, including amino alcohols, were efficiently oxidized into their corresponding carbonyl compounds under mild conditions with lower amounts of the catalysts.
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