Development of radical reaction using bromoalkynes and synthesis of natural products
| Project/Area Number |
25860013
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Hoshi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ラジカル環化反応 / ヨウ化サマリウム / ハロアルキン / アルデヒド / ケトン / ブロモアルキンとアルデヒド / クロロアルキンとアルデヒド / ブロモアルキンとケトン / ブロモアルキン |
|---|
| Outline of Final Research Achievements |
Radical reaction is the most of important reactions in organic chemistry to form carbon-carbon bonds and carbon-halogen bonds, which applied to synthesize natural products, medicines and polymer. Therefore, it is important to develop a new and a efficient methodology. We have successfully developed that SmI2-mediated reductive cyclization of haloalkynes with aldehydes, affording (Z)- bromoallyl alcohol in good to excellent yields. Further, radical cyclization of haloalkynes with ketones are under investigation of our laboratory.
|
Report
(3 results)
Research Products
(3 results)
